谷胱甘肽硫转移酶基因表达的调控  

Regulation of Glutathione S-Transferase Gene Expression

作　　者：庞战军[1] 陈瑗[1] 周玫[1] 

机构地区：[1]第一军医大学自由基医学研究室,广州510515

出　　处：《生物化学与生物物理进展》1997年第5期401-405,共5页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金资助项目! (396 70 197)

摘　　要：催化内源性或外源性亲电子化合物与谷胱甘肽 (GSH)结合的谷胱甘肽硫转移酶 (GST)超基因家族是一族解毒功能蛋白 .其基因的表达通过不同的机制受多种物质的调控 .根据最近文献资料 ,对调控谷胱甘肽硫转移酶基因表达的基因结构。The proteins expressed by the glutathione S-transferase(GST) supergene family which catalyze the conjugation of endogenous or exogenous electrophiles with glutathione(GSH) are a family of detoxicating proteins,the gene expression of which is regulated by many sorts of compounds through different mechanisms. A brief review for the gene structure and regulation mechanisms associated with the expression of GSTs,and the action of oxidative stress in the regulation of GST gene expression was made.

关 键 词：谷胱甘肽硫 转移酶 基因调控 基因表达 

分 类 号：Q555.6[生物学—生物化学]