光敏纳米脂质体制备及其特性研究  

Preparation and characterization of photosensitive liposomes

作　　者：温演庆[1] 杨斌[1] 钱志勇[2] 

机构地区：[1]四川省出入境检验检疫局,四川成都600041 [2]四川大学华西医院生物治疗国家重点实验室,四川成都610041

出　　处：《中国医学工程》2008年第2期84-85,共2页China Medical Engineering

基　　金：国家质检总局科技项目(No:2007IK130)

摘　　要：目的制备聚丁二炔光敏纳米脂质体并对其特性进行研究。方法采用反相蒸发法制备聚丁二炔纳米脂质体,原子力显微镜观察脂质体形态,激光粒度分析仪测定脂质体粒径与表面电位。结果制备的光敏纳米脂质体形状规则,平均粒径(78.3±1.4)nm。结论采用反相蒸发法制备的聚丁二炔纳米脂质体,达到设计要求。[Objective] To prepare photoallergic nano-liposeme containing polydiacetylene and to study its characteristics. [Methods] The liposome is prepared by reverse phase evaporation. Its morphous is observed by atomic force microscope, and its grain size and surface potential are determined. [Results] The figure of photoallergic nano-liposeme appears regulated and its nmean diameter is （78.3±1.4） nm. The nano-fiposome can be conserved over 18 months under 4℃. [ Conclusion] The photoallergie nano-liposome prepared by reverse phase evaporation achieves request of design.

关 键 词：丁二炔 纳米脂质体 

分 类 号：R445.9[医药卫生—影像医学与核医学]