恶性消化道肿瘤在2型糖尿病患者中的分布特点  

Distributing characteristics of digestive malignancy in type 2 diabetic patients

作　　者：王爱萍[1] 饶亚平[1] 刘超[2] 蒋克春[1] 王伟[1] 

机构地区：[1]解放军第454医院内分泌科,江苏南京210002 [2]南京医科大学附属第一医院内分泌科,江苏南京210006

出　　处：《医学研究生学报》2008年第7期742-744,共3页Journal of Medical Postgraduates

摘　　要：目的:探讨2型糖尿病患者并发恶性消化道肿瘤的分布特点,为糖尿病患者预防恶性肿瘤,主要是消化道恶性肿瘤的发生提供帮助。方法:调查2000年至2005年资料相对完整的所有含有2型糖尿病的死亡患者,找出合并恶性肿瘤的患者,再找出其中恶性消化道肿瘤,从性别和分布等角度来分析肿瘤分布规律。结果:死亡的2型糖尿病患者有201例,女75例、男126例,57例合并恶性肿瘤[女13例、男44例,死亡年龄(73.53±9.03岁)]。肿瘤大多好发于男性。消化道肿瘤达25例,占糖尿病总人数的(12.44%)最高,其后依次为血液系统肿瘤、肺部肿瘤和泌尿系统肿瘤。消化道肿瘤在各器官中分布又有所不同,胰腺癌最高(4.48%),而胃癌、食道癌、胆囊癌仅占糖尿病总人数的0.498%,肝癌、肠癌等肿瘤居中;糖尿病至肿瘤病程以胰腺癌最短(仅在3年左右),而肠癌最长(在11年左右),其他类型肿瘤居中。结论:2型糖尿病患者易合并恶性肿瘤,尤其是消化道恶性肿瘤;且男性较女性好发。肿瘤在胰腺、肝脏和肠道等器官的表现(包括患病率和糖尿病至肿瘤病程)有所不同。Objective：To study the distributing characteristics of digestive malignancy in patients with type 2 diabetes mellitus. Methods：We reviewed the complete data of 201 dead patients with type 2 diabetes mellitus from 2000 to 2005, sifted those complicated by cancer and those by digestive malignancy, and then analyzed the distributing characteristics and morbidity of the tumor. Results： The patients （ 126 males and 75 females） died at the average age of （73.53 ±9.03） years. Of the total number, 57 cases （44 males and 13 females） were complicated by cancer and 25 （22 males and 3 females） by digestive malignancy, the latter constituting the largest proportion of the diabetic patients （12.44%）, followed by malignancy of the blood system, the lung and the urinary system. The pancreas was involved in 4.48% of the cases, while the stomach, esophagus, gallbladder and other digestive organs in only 0. 498% of them. Of all the patients, those complicated by pancreatic cancer ran a shortest disease course of about 3 years, while those with the colon involved a longest course of about 11 years Conclusion ： Patients with type 2 diabetes mellitus are liable to cancer, particularly to digestive malignancy, and males are more susceptible than females. The cancerous characteristics, including morbidity and disease course, vary in different digestive organs .

关 键 词：2型糖尿病 消化道恶性肿瘤 分布 

分 类 号：R587.1[医药卫生—内分泌]