维生素K缺乏与骨损害的关系  

Relationship between Vitamin K deficiency and bone damage

作　　者：陈双叶[1] 张雪娟[1] 王洪涛[2] 

机构地区：[1]中国医科大学,89期七年制沈阳110001 [2]中国医科大学附属盛京医院血液科,沈阳110004

出　　处：《实用药物与临床》2008年第4期241-242,共2页Practical Pharmacy and Clinical Remedies

摘　　要：维生素K(VK)是特异性骨蛋白中谷氨酸进行翻译后γ-羧化的酶促反应中重要的辅助因子,也是甾族和异生素受体(SXR)介导下维持骨稳态的信号网路中某些基因的转录调节子。此外,VK对骨质再吸收,破骨效应以及炎症反应起着一定的抑制作用。本文对以上几方面进行综述,也提出关于VK在骨代谢方面一些未知的问题,旨在发掘出VK缺乏与骨损害的关系。Vitamin K is a necessary cofactor for post-translational γ-carboxylation of glutamic acid in the enzymatic reaction of specific bone proteins.It also serves as a transcriptional regulator of certain genes through the signaling network in bone homeostasis mediated by Steroid and Xenobiotic Receptor（SXR）.Besides,vitamin K plays a part in inhibitory action of bone resorption,osteoclastogenesis and inflammatory reaction.The author summarizes the actions of vitamin K in bone metabolism,proposes several relative problems to be resolved,aims at uncovering the relationship between vitamin K deficiency and bone damage.

关 键 词：维生素K缺乏 骨损害 临床分析 治疗方法 

分 类 号：R591.49[医药卫生—内科学]