荷移光度法测定药物中的氨吡酮  

Spectrophotometric Determination of Amrinone in Pharmaceutical Preparations Based on Charge Transfer Complex

作　　者：徐变珍[1] 赵凤林[1] 童沈阳[1] 

机构地区：[1]北京大学化学与分子工程学院

出　　处：《北京大学学报（自然科学版）》1997年第6期716-719,共4页Acta Scientiarum Naturalium Universitatis Pekinensis

基　　金：国家自然科学基金

摘　　要：用分光光度法研究了氨吡酮与四氯苯醌之间的荷移反应，确立了反应的最佳条件。在乙醇介质中，氨吡酮与四氯苯醌形成１１络合物，其λｍａｘ＝４０９ｎｍ，表观摩尔吸光系数为５．８６×１０３Ｌｍｏｌ－１ｃｍ－１。氨吡酮含量在４０ｍｇ／Ｌ范围内呈线性关系，工作曲线回归方程为Ａ＝０．００７２０＋０．０３０９５ｃ，相关系数ｒ＝０．９９９８。方法重现性好，重复实验相对标准偏差小于２％。应用拟定方法测定药物制剂中氨吡酮含量与卫生部标准方法测定结果一致，回收率可达９９％以上。The charge transfer complex(CTC) of chloranil with Amrinone was studied in detail by spectrophotometry.A new method for the determination of Amrinone has been established.The determinations were carried out in ethanol solution at 409nm.Beer′s law is obeyed in the concentration range of 0￣40mg/L.The apparent molar absorptivity was 5 86×10 3 L·mol -1 ·cm -1 .The composition is 1∶1.The proposed method was applied to determination of Amrinone in pharmaceutical preparations and satisfactory result was obtained.

关 键 词：荷移反应 分光光度法 氨吡酮 强心药物 

分 类 号：R972.1[医药卫生—药品] R914.1[医药卫生—药学]