酶促开环聚合和原子转移自由基聚合制备新型H型嵌段共聚物  

Synthesis of Novel H-shaped Block Copolymer by the Combination of Enzymatic-Promoting Ring-opening Polymerization and ATRP

作　　者：王迪[1] 张宝[1] 李亚鹏[1] 孙景辉[2] 

机构地区：[1]吉林大学化学学院麦克德尔料德实验室,长春130012 [2]吉林大学第一临床医院,长春130023

出　　处：《高等学校化学学报》2008年第7期1479-1482,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20574028)资助

摘　　要：在生物酶催化剂Novozyme-435的作用下,乙二醇引发己内酯(ε-CL)酶促开环聚合,再用三乙胺作催化剂,将PCL端羟基与2,2-二氯代乙酰氯反应,生成四官能度大分子引发剂,引发甲基丙烯酸环氧丙酯(GMA)的原子转移自由基聚合(ATRP),合成了H型三嵌段共聚物(PGMA)2-b-PCL-b-(PGMA)2.嵌段共聚物的结构通过核磁共振和凝胶渗透色谱(GPC)得到了确证,其多分散性为1.32,分子量为32000.通过差热扫描量热法对嵌段共聚物的热性能进行了研究.Enzymatic-promoting ring-opening polymerization （ROP） of ε-caprolactone （ε-CL） was performed in the presence of biocatalyst Novozyme-435 and initiator ethylene glycol. The resulting polymer was esterified with 2,2-Dichloro acetyl chloride（DCAC） to obtain macroinitiator, which can be used in the following ATRP of the glycldyl methacrylate（GMA） using CuC1/2,2＇-blpyridine as the catalyst system to synthesize the well-defined H-shaped block copolymer（PGMA） 2-b-PCL-b-（PGMA） 2. The structure of the polymer was characterized via GPC and ^1H NMR analysis. The polydisperisty of the resulting H-shaped block copolymer is 1.32, Mn = 32000. The thermal properties of block copolymer was characterized by differential scanning calorimetry.

关 键 词：H型嵌段共聚物 原子转移自由基聚合 酶促开环聚合 甲基丙烯酸环氧丙酯 

分 类 号：O631[理学—高分子化学]