层状水凝胶仿生软骨的制备与性能  

Preparation and Properties of Two-layer Integrative Hydrogel as Biomimetic Cartilage Replacement Material

作　　者：王迎军[1] 徐红[1] 郑裕东[2] 任力[1] 

机构地区：[1]华南理工大学材料科学与工程学院 [2]北京科技大学材料科学与工程学院,北京100083

出　　处：《高等学校化学学报》2008年第7期1488-1491,共4页Chemical Journal of Chinese Universities

基　　金：国家“九七三”计划(批准号:2005CB623902);国家自然科学基金(批准号:50403023);广东省自然科学基金团队项目(批准号:04205786)资助

摘　　要：采用超声分散、高压加热共融、冷冻-熔融和γ射线辐照交联成型工艺制备层状水凝胶仿生软骨材料，系统讨论了PVP添加量和辐照剂量对材料的凝胶含量、晶态结构及抗压缩弹性模量的影响，观察和研究了层状水凝胶的微观结构。研究结果表明，随着PVP的质量分数（0-40％）和辐照剂量（0-60 kGy）的增加，层状水凝胶的凝胶含量呈上升趋势；其晶态结构在质量分数为20％的PVP和10 kGy辐照剂量下最完善；其力学性能在质量分数为20％的PVP和20 kGy辐照剂量下最佳；PVP的加入改善了水凝胶的微观形貌，有利于材料表面润滑性能的提高；层状水凝胶层间渗透结合，自然过渡，形成结构良好的仿生软骨材料。Two-layer integrative hydrogels were prepared as biomimetic articular cartilage replacement materials through ultrasonic dispersion, heat-high-pressure, freeze/thawed and radiation technique. The effects of PVP mass fraction and irradiation dose on the gel content, crystallinity structures and elastic compress modulus were investigated. The microstructures of the two-layer integrative hydrogels were also characterized. It was found that the gel content increased with the increase of PVP mass fraction （0--40%） and irradiation dose （0--60 kGy）. The crystallinity of PVP-PVA composite hydrogel is the highest under 10 kGy irradiation dose and 20% PVP. Two-layer integrative hydrogel with 20% PVP under 20 kGy irradiation dose showed the highest elastic compress modulus. SEM results show that the surface structures of PVP-PVA composite hydrogels were improved with increasing the PVP mass fraction. SEM results also indicate that the integrative hydrogel showed a good compatibility between top-layer and underlayer. Based on the above results, the two-layer integrative hydrogel showed a promoting prospect as biomimetic cartilage replacement material.

关 键 词：软骨 水凝胶 聚乙烯醇 聚乙烯吡咯烷酮 

分 类 号：O631[理学—高分子化学]