猪去氧胆酸分子裂缝的微波合成  

Synthesis of Molecular Clefts Based on Hyodeoxycholic Acid under Microwave Irradiation

作　　者：易奉敏[1] 赵志刚[1] 陈静[1] 赵潇湘[1] 

机构地区：[1]西南民族大学化学与环境保护工程学院,四川成都610041

出　　处：《合成化学》2008年第4期423-427,共5页Chinese Journal of Synthetic Chemistry

基　　金：西南民族大学博士创新基金资助项目(08NBS002)

摘　　要：在微波无溶剂辐射条件下,以猪去氧胆酸为隔离基,芳香族化合物为手臂合成了一类新型手性分子裂缝,其结构经1H NMR,IR,MS和元素分析确证。考察了微波辐射条件对反应的影响,结果表明,以固体K2CO3为载体,于460W辐射4min,收率最高(90%)。A novel type of chiral molecular tweezers were synthesized by using hyodeoxycholic acid as a spacer and aromatic compounds as a arm in solvent-free under microwave irradiation. Their struc- tures were confirmed by ^1 H NMR, IR, MS and elemental analysis. The effect of microwave irradiation conditions on the reaction were investigated. The results showed that the yield of product was 90% at 460 W for 4 min using K2CO3 as a supporter.

关 键 词：猪去氧胆酸 分子裂缝 分子识别 微波合成 

分 类 号：O641.3[理学—物理化学]