紫苏叶提取物对高脂血症家兔血脂及脂质过氧化的影响  

The Effects of Folium Perillae Extract on Blood Fat and Lipid per Oxidation of Rabbit with Hyperlipemia

作　　者：谭健民[1] 陈眷华[1] 徐在品[1] 霍欣[1] 邓小燕[2] 张迪[1] 简秀华 

机构地区：[1]贵州大学动物科学学院动物医学系,贵州贵阳550025 [2]北京航空航天大学生物工程系,北京100083 [3]贵州省贵阳市花溪农业局,贵州贵阳550025

出　　处：《安徽农业科学》2008年第18期7701-7702,7723,共3页Journal of Anhui Agricultural Sciences

基　　金：国家自然科学基金资助项目(10572029;10632010;107-72054)

摘　　要：[目的]观察紫苏叶提取物(FPE)对家兔高脂血症的防治作用。[方法]采用高脂饮食,建立家兔高脂血症模型,分别测定正常对照组、高脂模型组、紫苏叶提取物低剂量组(0.17g/kg)、中剂量组(0.5g/kg)、高剂量组(1.5g/kg)血清中TC、TG、LDL-C、HDL-C、MDA含量及SOD的活性。[结果]FPE(0.17g/kg、0.5g/kg、1.5g/kg)组均能显著降低血清中TC、TG、LDL-C、MDA的含量(P<0.01),并能提高血清中HDL-C的含量(P<0.01)和SOD的活性(P<0.05)。[结论]FPE具有一定的调节血脂及抗脂质过氧化的作用。[Objective]The preventive and therapeutic effects of Folium perillae extmet（FPE） on hyperlipemia induced by feeding rabbit with high fat forage were observed. [Method] The high fat and cholesterol diet were adopted to create the hyperlipemia model of rabbit.The rabbits were randomly and equally divided into 5 groups which were NC（normal control）group,HLM （high lipid model） group,LFPE,MFPE and HFPE group （low,middle,high dosage of FPE were 0.17 g/kg,0.5 g/kg and 1.5 g/kg respectively）. The contents of TC, TG, LDL-C, HDL-C, MDA and the activity of SOD in serum were detected respectively. [ Result] The three FPE groups could decrease the contents of TC, TG, LDL-C, MDA significantly （P 〈 0.01 ） compared with these of HLM group, and the contents of HDL-C （ P 〈 0.01 ）） and the activity of SOD （ P 〈 0.05） in serum was increased significantly. [ Conclusion ] FPE could regulate blood-fat and counteract lipid peroxidation.

关 键 词：紫苏叶提取物 血脂 丙二醛 超氧化物歧化酶 

分 类 号：S829.1[农业科学—畜牧学]