TUVP联合激素全阻断治疗晚期前列腺癌PSA分析  

Study of PSA in patients with advanced prostate cancer combined use of TUVP and maximal androgen blockade

作　　者：汪灶昆 陈卫民[2] 顾继礼 李俊[2] 栾翠芳 戴雨梅 陈仪 王国成 

机构地区：[1]扬州大学附属泰兴市人民医院泌尿外科,江苏泰兴225400 [2]江西医学院第一附属医院泌尿外科,江西南昌330006

出　　处：《中国现代医学杂志》2008年第14期2052-2054,共3页China Journal of Modern Medicine

摘　　要：目的探讨TUVP联合雄激素全阻断(MAB)治疗晚期前列腺癌的有效方法以及血PSA水平变化。方法应用经尿道前列腺电汽化术(TUVP)治疗合并膀胱出口梗阻(BOO)前列腺癌患者68例,结合MAB治疗。结果68例患者手术成功,疗效满意,无并发症,术后分别随访3个月￣3年。国际前列腺症状评分(IPSS)由术前的(27.6±3.8)分下降到术后2个月(9.4±2.1)分(P<0.05);PSA由术前(67.2±5.3)μg/L、术后30min(65.8±6.4)μg/L下降到术后2个月的(5.6±1.8)μg/L(P<0.05)。结论应用TUVP联合MAB是治疗Pca合并BOO有效方法。但TUVP治疗晚期前列腺癌是否引起癌转移须进一步研究。[Objective] To investigate a surgical method of transurethral vaporization of the prostate and maximal androgen blockade for the treatment of prostate cancer with bladder outlet obstruction and the level change of PSA. [Methods]68 patients with prostate cancer complicated with bladder outlet obstruction were treated by combined use of transurethral vaporization of the prostate （TUVP） and maximal androgen blockade after operation. [Results] The operations were successful, with satisfactory results and no serious complication. The patients have been followed up for three months to three years respectively. IPSS decreased from （27.6±3.8） preoperatively to （9.4±2.1） postoperatively （P 〈0.05）, and PSA decreased from （67.2±5.3） μ g/L before operation and androgen blockade and PSA （65.8±3.6）μg/L 30 minute after operation immediately to （3.6±1.8） μg/L two month after operation （P 〈0.01）. [Conclusion] The combined use of TUVP- and maximal androgen blockade is a safe and ideal method for the treatment of prostate cancer with bladder outlet obstruction. Whether the treatment of transurethral vaporization of the prostate will cause the metastases in operation is needed study.

关 键 词：前列腺癌 膀胱出口梗阻 经尿道前列腺电汽化术 雄激素全阻断 转移 

分 类 号：R737.25[医药卫生—肿瘤]