蜘蛛丝蛋白的模块结构性能和重组表达  

Modular Structures and Recombinant Expression of Spider Silk Proteins

作　　者：周培[1] 邹竹荣[1] 曹丽娟[1] 苏裕[1] 

机构地区：[1]华东师范大学生命科学学院,上海200062

出　　处：《生物技术通讯》2008年第4期623-625,共3页Letters in Biotechnology

基　　金：上海市科委纳米科技专项(05nm05016)

摘　　要：蜘蛛丝是一类天然蛋白质纤维,具有独特的机械性能(高强度、高弹性和高断裂功等)和卓著的生物学特性(生物可降解性和与生物组织的相容性等),在生物医学、材料、纺织和军事等领域都有着很高的潜在应用价值。综述了不同蜘蛛丝蛋白的模块结构特征及与其功能的关系,扼要介绍了目前利用各种基因工程方法表达重组蜘蛛丝蛋白的研究进展。Spider silks,being a class of nature protein fibers,have a large potential of applications in the biomedical,material,textile and military areas,due to their unique mechanical features of high strength,elasticity and energy to break,and eminent biological peculiarities in terms of biodegradability and compatibility to the biological tissues.This mini-review summarized the current understanding of different spider silk proteins in respect of the structural modules and their functional correlations,and the major proceedings in utilizing various genetic approaches to produce the recombinant spider silk proteins.

关 键 词：蜘蛛丝蛋白 分子模块 结构和功能 重组表达 

分 类 号：Q51[生物学—生物化学] Q78