溶脲脲原体感染与中国男性不育关系的Meta分析  

A Meta-Analysis of Ureaplasma urealyticum Infection and Chinese Male Infertility

作　　者：刘德风[1] 姜辉[1] 洪锴[1] 赵连明[1] 唐凌峰[1] 柳建明[1] 马潞林[1] 李斌[2] 

机构地区：[1]北京大学第三医院泌尿外科,北京100083 [2]吉林大学白求恩医学部,吉林长春130021

出　　处：《中华男科学杂志》2008年第7期618-623,共6页National Journal of Andrology

摘　　要：目的:探讨溶脲脲原体感染与中国男性不育的关系。方法:根据资料一致性检验结果,采取随机效应模型,对检索到的49篇有关溶脲脲原体感染与中国男性不育的文章利用RevMan4.2.2进行综合定量分析。比较采取不同样本量大小对研究结论的影响,同时分别分析培养检测和PCR检测的灵敏度。结果:溶脲脲原体感染与中国男性不育有明显关系,按不同样本量纳入文献,第1次结论为OR=4.43(95%CI:3.77～5.22);培养变色检测和PCR检测的OR值分别为4.25(95%CI:3.59～5.03)和5.35(95%CI:3.37～8.47);第2次结论OR=4.28(95%CI:3.52～5.20);培养变色检测和PCR检测的OR值分别为4.24(95%CI:3.41～5.28)和4.42(95%CI:2.73～7.17)。结论:溶脲脲原体感染和中国男性不育有明显关系;样本量大小对研究结论有明显影响,应合理设计试验样本量;PCR检测比培养检测具有更高的灵敏度。Objective：To investigate the correlation between Ureaplasma urealyticum infection and infertility in Chinese males.Methods：According to the results of the heterogeneity test,a comprehensive quantitative analysis was made of 49 papers on Ureaplasma urealyticum infection and Chinese male infertility by RevMan 4.2.2.The impacts of different sample volumes on the research findings were compared,and the sensitivities of culture and PCR detections analyzed respectively.Results：Ureaplasma urealyticum had a significant negative impact on Chinese male fertility.Based on different samples of literature,two rounds of screening and analysis were carried out and two different conclusions derived.The first was OR=4.43（95% CI：3.77-5.22）,with the OR values of culture and PCR detections as 4.25（95% CI：3.59-5.03）and 5.35（95% CI：3.37-8.47）,and the second was OR=4.28（95% CI：3.52-5.20）,with the OR values of culture and PCR detections as 4.24（95% CI：3.41-5.28）and 4.42（95% CI：2.73-7.17）.Conclusion：There is a significant correlation between Ureaplasma urealyticum and Chinese male infertility.The conclusion of study is significantly influenced by the sample volume,which should be reasonably designed.The sensitivity of PCR detection is higher than that of culture detection.

关 键 词：溶脲脲原体 男性不育 PCR检测 培养检测 META分析 

分 类 号：R698.2[医药卫生—泌尿科学]