Tracerlab FX-FN合成^(18)F-FLT过程质量控制  

Quality Control of the Process to Synthesize ^(18)F-FLT with Tracerlablab FX-FN

作　　者：梁秀艳[1] 胡玉民[1] 王文志[1] 于丽娟[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院PET/CT中心,黑龙江哈尔滨150081

出　　处：《中国医疗设备》2008年第7期97-98,共2页China Medical Devices

摘　　要：18F-FLT(3′脱氧-3′18F-氟代胸苷)可进行细胞增殖显像,在PET及PET/CT对肿瘤的诊断中有很广阔的应用--前景。但困扰其研究及临床应用的最大问题是合成产率低及重复性差,本文总结了TracerlabFX-FN在采用5′-O-Ben-zoyl-2,3′-anhydrothymidine(BAThy)前体亲核取代合成F-FLT过程中的质量控制因素,对获得较理想的产率及良好重复性18起到了积极有效的作用。^18F-FLT （3＇-deoxy-3＇-^18F- fluorothymidine） is used in the image cellular proliferation by PET, which is expected to be an excellent PET tracer for diagnosing and evaluating the response of therapy in oncology. However, the low synthesis yield and repetition limit widely the clinical application. This paper sums up the effectual quality control methods for the process to synthesize ^18F-FLT with Tracerlab FX-FN, which is nucleophilic substitution labeling with 5＇ -O-Benzoyl-2,3＇ -anhydrothymidine （BAThy） as a precursor.

关 键 词：PET/CT Tracedab FX-FN合成 合成^18F-FLT 

分 类 号：R814.42[医药卫生—影像医学与核医学]