化疗致粒细胞缺乏症患者发热与感染的关系  

Correlation of Fever to Infection in Patients with Chemotherapy-induced Neutropenia

作　　者：阮燕萍[1] 张文英[1] 

机构地区：[1]浙江省肿瘤医院院感科,浙江杭州310022

出　　处：《癌症》2008年第8期879-881,共3页Chinese Journal of Cancer

摘　　要：背景与目的:恶性肿瘤化疗后粒细胞缺乏症患者常继发发热和感染,但临床对发热患者是否存在感染持有异议。本研究旨在了解化疗致粒细胞缺乏症患者发热及感染的发生情况,并探讨两者之间的关系。方法:调查2007年1月至7月,因化疗致粒细胞缺乏症在浙江省肿瘤医院住院的256例恶性肿瘤患者,对其中发生发热及感染的病例进行描述性分析和一致性检验。结果:256例病例中共发生发热100例(39.1%),感染42例(16.4%)。发热者体温(39.0±0.6)℃。感染部位主要见于咽部(42.9%)、口腔(21.4%)和下呼吸道(14.3%)。发热与感染病例一致性检验结果Kappa值为0.414(P<0.001),一致率为0.75。结论:化疗致粒细胞缺乏症者发热及感染的发生率较高,且发热与感染呈中度一致。BACKGROUND ＆ OBJECTIVE： The cancer patients with chemotherapy-induced neutropeina often suffer from fever and infection, but current opinions on the correlation of the fever to infection are controversial. This study aimed to investigate the incidence and correlation of fever and infection in cancer patients with chemotherapy-induced neutropenia. METHODS. Clinical data of 256 in-patients with chemotherapy-induced neutropenia from Jan. to Jul. 2007 were analyzed. The occurrence of fever and infection in these patients were analyzed by using descriptive analysis and agreement test. RESULTS,, Of the 256 patients, 100 （39.1%） suffered from fever, and 42 （16.4%） experienced infection. The temperature of febrile patients was （39.0±0.64）℃. The main sites of infection were the pharynx （42.9%）, oral cavity （21.4%） and low respiratory tract （14.3%）. The consistency rate was 0.75 between fever and infection （Kappa=0.414, P〈 0.001）. CONCLUSION： The incidence of fever and infection in cancer patients with chemotherapy-induced neutropenia are high with a moderate agreement between fever and infection.

关 键 词：肿瘤 化学疗法 粒细胞缺乏症 发热 感染 

分 类 号：R595.3[医药卫生—内科学]