PB1结构域与细胞信号转导  

PB1 Domain and Signal Transduction Pathway

作　　者：薄秀梅[1] 周天华[1] 刘训言[1] 

机构地区：[1]浙江大学医学院解剖学与细胞生物学教研室,杭州市310058

出　　处：《医学分子生物学杂志》2008年第4期356-360,共5页Journal of Medical Molecular Biology

摘　　要：PB1(Phox and Bem1)结构域是一种约由80个氨基酸残基组成的功能性结构域,主要有3种类型。它存在于许多信号转导蛋白中,并介导这些蛋白之间的二聚化。这些PB1结构域蛋白主要参与两条信号转导通路,即丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)信号通路和细胞核因子κB(NF-κB)信号通路。同时,PB1结构域与许多肿瘤如乳腺癌、肺癌的发生发展密切相关。PB1 （Phox and Bend ） domain is a functional domain comprising about 80 amino acid residues, which consists of three types, which exist in many signal transduction proteins and mediates dimerization in the proteins. PB1 domain is mostly involved in two signal transduction pathways, MAPK and NF-kB. In addition, PB1 domain is closely related to tumorigenesis and progression of tumor, for instance, breast and lung cancer.

关 键 词：PB1结构域 信号转导 肿瘤 

分 类 号：R373[医药卫生—病原生物学]