SSTF预处理对脑缺血再灌注大鼠海马微血管的影响  

EFFECTS OF SSTF PRETREATMENT ON MICROVESSELS OF HIPPOCAMPUS OF CEREBRALISCHEMIAAND REPERFUSION RATS

作　　者：赵淑敏[1] 周虹九 韩莉[1] 马卫军[1] 刘胜[1] 

机构地区：[1]承德医学院电镜室,河北承德067000 [2]承德市妇幼保健院

出　　处：《承德医学院学报》2008年第3期236-238,共3页Journal of Chengde Medical University

基　　金：河北省科技厅资助项目(07276101D-46)

摘　　要：目的:探讨黄芩茎叶总黄酮(SSTF)预处理对脑缺血再灌注大鼠海马微血管构筑的影响。方法:SSTF预处理实验大鼠,制备缺血再灌注模型,光镜观察海马微血管形态及数量的变化并进行定量分析。结果:缺血再灌注组(IR组)大鼠海马微血管缺失,部分微血管闭塞。SSTF预处理组大鼠海马微血管数量较IR组大鼠增多(P<0.01),闭塞血管数量减少,微血管密度(MVD)、微血管面积密度(MVA)明显高于IR组(P<0.01)。结论:SSTF预处理可能通过防止微血管因缺血闭塞,增强再灌注后微血管再通能力来保护海马组织。Objective：To observe the effects,of scutellaria baicalensis stem-leaf tatal flavonoid （SSTF） pretreatment on microvascular architecture of hippocampus of cerebral ischemia and reperfusion rats.Methods： The rats were pretreated with SSTF,then the ischemia and reperfusion （IR） rats model were established.The morphology and amount of microvessels of hippocampus were observed under light microscope and quantitatively analyzed.Results：In IR rats hippocampus,the microvessels missed and part of the microvessels blocked. The amount of microvessels in SSTF pretreatment rats hippocampus obviously increased compared with IR rats （P 〈 0.01）;The blocking microvessels decreased, MVD and MVA increased obviously compared with IR rats （P 〈 0.01）.Conclusions：SSTF pretreatment can protect hippocampus by preventing microvessels blocking induced by missing and strengthening the perfusing ability after reperfusion.

关 键 词：黄芩茎叶总黄酮(SSTF) 预处理 缺血再灌注 微血管 海马 

分 类 号：R285.5[医药卫生—中药学]