舒马普坦对电刺激上矢状窦后大鼠硬脑膜血流量的影响  

Effect of Sumatriptan on Dura Blood Flow Induced by Electric Stimulation of Superior Sagittal Sinus in Rats

作　　者：董钊[1] 于生元[1] 赵秀梅[2] 姜磊[1] 李凤鹏[1] 刘若卓[1] 邱恩超[1] 

机构地区：[1]中国人民解放军总医院神经内科,北京100853 [2]中国人民解放军总医院病理生理研究室,北京100853

出　　处：《微循环学杂志》2008年第3期20-21,24,共3页Chinese Journal of Microcirculation

基　　金：国家自然科学基金(30570264)

摘　　要：目的:观察电刺激上矢状窦区后大鼠硬脑膜血流量的变化以及舒马普坦对其的影响。方法:18只SD大鼠随机分为对照组、电刺激组和舒马普坦组,暴露大鼠上矢状窦区硬脑膜,电刺激组和舒马普坦组以30Hz、6V和0.25ms的刺激参数建立偏头痛模型,激光多普勒血流量图像仪测定硬脑膜血流量,比较各组大鼠相对血流量的变化。结果:对照组、电刺激组以及舒马普坦组的相对血流量分别为2.61±4.43%、15.49±5.65%和-0.35±5.08%,组间差异有非常显著性统计学意义(P<0.01);电刺激组分别与对照组及舒马普坦组行两两比较,差异有非常显著性统计学意义(均P<0.01);对照组与舒马普坦组比较,差异无统计学意义。结论:高频电刺激上矢状窦区能增加大鼠硬脑膜血流量,舒马普坦对其有抑制作用。Objective:To analyze the change of dura matter blood flow induced by electric stimulation on superior sagittal sinus and the effect of sumatriptan in rats.Method:Eighteen male SD rats were randomly divided into control,electric stimulation and sumatriptan group.Dual matter adjacent to the superior sagittal sinus was stimulated applying parameters of 30 Hz,6 V and 0.25 ms and laser doppler perfusion imager(LDI) was used to measure dual matter blood flow in different groups.Results:The relative blood flow of control,electric stimulation and sumatriptan group was(2.61±4.43)%,(15.49±5.65)% and(-0.35±5.08)% respectively.Significant difference(both P<0.01) existed among electric stimulation group and other groups;However,the comparison between control group and sumatriptan group showed no significant difference.Conclusion:Electric stimulation on superior sagittal sinus can increase dura matter blood flow which is able to be inhibited by sumatriptan.

关 键 词：脑膜血流量 舒马普坦 上矢状窦 电刺激 大鼠 抗偏头痛药物 动物模型 原发性头痛 

分 类 号：R971[医药卫生—药品] R971.9[医药卫生—药学]