网织红细胞参数在聚乙二醇干扰素α治疗慢性丙型肝炎中的应用  

The Observation of Reticulocyte Parameters in Chronic Hepatitis C with IFN treating

作　　者：杨小娟[1] 吴国荣[2] 陆忠华[3] 

机构地区：[1]江苏省无锡市传染病医院检验科,无锡214005 [2]无锡市人民医院医学检验科 [3]无锡市传染病医院肝病科

出　　处：《微循环学杂志》2008年第3期59-60,共2页Chinese Journal of Microcirculation

摘　　要：目的:通过分析网织红细胞(Ret)参数变化,了解慢性丙型肝炎患者聚乙二醇干扰素α(PEG-IFN-α)治疗过程中及治疗结束后骨髓造血功能的抑制和恢复情况。方法:采用血细胞分析仪检测37例治疗过程中患者外周血白细胞(WBC)、中性粒细胞绝对值(ANC)、网织红细胞百分比(Ret%)、网织红细胞绝对值(Ret#)及未成熟网织红细胞指数(IRF)的变化。20例健康体检者作为正常对照组。结果:HCV患者从PEG-IFN-α治疗第2周开始,Ret%、Ret#、IRF即显著低于治疗前和对照组,WBC、ANC于治疗4周开始显著减低;IRF、Ret%、Ret#在治疗结束后第1周开始恢复,WBC、ANC在治疗结束后第2周开始恢复。结论:Ret各参数用于了解慢性丙型肝炎患者PEG-IFN-α治疗后骨髓造血功能的抑制和恢复情况,其敏感性高于WBC和ANC。Objective:To investigate the change of reticulocyte parameters:reticulocyte percent(RET%),absolute reticulocyte count(RET#),immature reticulocyte fraction(IRF) in chronic Hepatitis C with PEG-IFN-α treating.Method:White blood cell(WBC) and reticulocyte parameters were measured automatically by Beckman-coulter LH-750 analyzer.Results:The change of reticulocyte parameters has significant difference(P<0.01) after two weeks between chronic Hepatitis C with PEG-IFN-αtreating and normal groups;one week after stop treating,IRF,RET% and RET# was normal.Conclusion:The change of reticulocyte parameters was very important in chronic Hepatitis C with PEG-IFN-α treating.

关 键 词：网织红细胞参数 聚乙二醇干扰素Α 慢性丙型肝炎 骨髓造血功能 治疗 检测技术 仪器检测 临床判断 

分 类 号：R556.3[医药卫生—血液循环系统疾病] R512.63[医药卫生—内科学]