血管内皮生长因子在恶性胸液中的表达水平及临床意义  

Expression and Clinical Significance of VEGF in Malignant Thorax Effusion

作　　者：崔艳红[1] 王明晖[1] 许尔屹[2] 姜飚[2] 

机构地区：[1]齐齐哈尔市第一医院,黑龙江齐齐哈尔161005 [2]黑龙江省医院,黑龙江哈尔滨150036

出　　处：《中国医学装备》2008年第8期42-43,共2页China Medical Equipment

摘　　要：目的:研究血管内皮生长因子在肺癌患者血清、胸水中的表达水平对肺癌的诊断及良恶性胸水鉴别诊断的价值。方法:采用酶联免疫吸附法检测36例肺癌患者血清与胸水VEGF含量。结果:肺癌组血清VEGF表达水平(127.56±85.72)ng/L与良性渗出液组(80.76±38.49)ng/L比较,差异有显著性;肺癌组胸水中VEGF表达水平(509.63±305.28)ng/L明显高于良性胸水(263.42±136.78)ng/L(<0.01)。结论:血清与胸水VEGF检测有助于肺癌的临床诊断和良恶性胸水的鉴别诊断,血清VEGF有可能与恶性胸水的形成有关。Objective：To determine the values of serum and thorax effusion levels of vascular endothelial growth factor（VEGF） in diagnosis of lung carcinoma and the values of serum and thorax effusion levels of VEGF in distinguishment diagnosis of benign and malignant thorax effusion. Methods：Serum and thorax effusion levels of VEGF were measured with enzyme linked immunosorbent assay（ELISA） in 56 patient with lung carcinoma. Results：Serum VEGF level in patients with lung carcinoma（127.56±85.72）ng/1 was significantly elevated as compared to those in patients with benign thorax sffusionThirax effusion （80.76±38.49）ng/1. Thorax effusion level of VEGF in lung carcinoma （509.63±305.28）ng/1 was significantly higher than those in patients with benign thorax effusion （ 263.42± 136.78）ng/1 （p〈0.01）. Conclusion：The mensuration of serum and thorax effusion levels of VEGF was helpful in clinical diagnosis of lung carcinoma and distinguishment diagnosis of benign and malignant thorax effusion. Serum VEGF is likely associated with formation of malignant thorax effusion.

关 键 词：血管内皮生长因子 恶性胸液 

分 类 号：R197[医药卫生—卫生事业管理]