氟比洛芬酯超前镇痛用于小儿扁桃体切除术的临床观察  

Clinical observation of flurbiprofen axetil injection preemptive analgesia in children undergoing tonsillectomy

作　　者：曾睿峰[1] 倪育飞[1] 王建光[1] 李军[1] 连庆泉[1] 

机构地区：[1]温州医学院附属第二医院麻醉科,325027

出　　处：《实用医学杂志》2008年第14期2488-2490,共3页The Journal of Practical Medicine

基　　金：浙江省医药卫生科研计划项目(编号:2004A071)

摘　　要：目的:观察氟比洛芬酯注射液(凯纷)超前镇痛用于小儿扁桃体切除术的镇痛效果及安全性。方法:择期行扁桃体切除术小儿60例,随机分为3组。A组于麻醉诱导前、B组于麻醉拔管后缓慢静注凯纷1mg/kg(用生理盐水稀释至5mL),C组以生理盐水5mL缓慢静注,注药时间均为2min。观察术后1、2、4、8、12、24h疼痛评分;凝血功能异常及恶心、呕吐等不良反应。结果:A组、B组术后各时点疼痛评分明显低于C组,A组也明显低于B组(P<0.05)。3组各时点均无呼吸抑制、凝血功能异常发生,3组术后恶心、呕吐等不良反应发生率差异无显著性(P>0.05)。结论:氟比洛芬酯超前镇痛较术后应用能有效减轻扁桃体切除术患儿术后急性疼痛,且无明显不良反应,可安全用于小儿术后镇痛。Objective To investigate the safety and efficacy of flurbiprofen axetil injection preemptive analgesia in children undergoing tonsillectomy. Methods Sixty children aged from 3 to 12 yr undergoing tonsillectomy were randomly divided into three groups. Patients in group A received flurbiprofen axetil injection at 1 mg/kg disage before anesthesia induction（diluted the drug to 5 mL with norulal saline）.Patients in group B received the same dosage after removal tracheal catheter. Patients in group C received 5 mL normal saline as control. Pain scores, coagulation disfunction, nausea and vomiting were observed at 1,2,4,8,12,24 h after operation. Results Pain scores in group C at all time points were significantly higher than those in group A and in group B （P 〈 0.05）. Pain scores in group B at all time points were significantly higher than those in group A （P 〈 0.05）. There were no difference in the incidence of respirator）, depression, coagulation disfunction, postoperative nausea and vomiting among three groups （P 〉 0.05）. Conclusion Flurbiprofen axetil injection could offer preemptive analgesia in children undergoing tonsillectomy with effectively and safely.

关 键 词：扁桃体切除术 镇痛 氟比洛芬酯注射液 小儿 超前镇痛 术后镇痛 

分 类 号：R726.1[医药卫生—儿科]