高迁移率族蛋白B-1与炎症关系的研究进展  

Relationship between high mobility group box-1 protein and inflammation

作　　者：刘旺华[1] 李花[2] 肖献忠[1] 

机构地区：[1]中南大学湘雅医学院病理生理学系 [2]湖南中医药大学基础医学院,湖南长沙410007

出　　处：《中国病理生理杂志》2008年第8期1656-1660,共5页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.30330280)

摘　　要：High mobility group box-1(HMGB1)distributed widely.It exists in many organs.HMGB1 locates in nuclei and cytoplasm in normal condition.It involves in many activity of life(i.e.,duplication of DNA,cellular differentiation,gene expression).The immunocytes(i.e.,mononuclear macrophage and dendritic cells)secrete HMGB1 into the extracellular milieu when stimulated with LPS and cytokines.It acts as proinflammatory cytokines,activates inflammatory and immunological responses.As a late mediators of inflammation and last long,HMGB1 plays an important role in sepsis,so it may be a convenient and practical index in evaluating severity of sepsis and may be an important and new therapeutic target in sepsis.It has been initially proved in experimental and clinical study.High mobility group box- l （HMGB1） distributed widely. It exists in many organs. HMGB1 locates in nuclei and cytoplasm in normal condition. It involves in many activity of life （ i. e. , duplication of DNA, cellular differentiation, gene expression）. The immunocytes （i. e. , mononuclear macrophage and dendritic cells） secrete HMGB1 into the extracellular milieu when stimulated with LPS and cytokines. It acts as proinflammatory cytokines, activates inflammatory and immunological responses. As a late mediators of inflammation and last long, HMGB1 plays an important role in sepsis, so it may be a convenient and practical index in evaluating severity of sepsis and may be an important and new therapeutic target in sepsis. It has been initially proved in experimental and clinical study.

关 键 词：高迁移率族蛋白质类 细胞因子类 脓毒症 

分 类 号：R631[医药卫生—外科学]