可溶性CD147与类风湿关节炎动脉粥样硬化危险因素的相关性  

The relationship between soluble CD147 and the risk factors of atherosclerosis in rheumatoid arthritis

作　　者：岳红红[1] 朱平[1] 冷南[1] 吴振彪[1] 李鸿明[1] 

机构地区：[1]第四军医大学西京医院临床免疫科,西安710032

出　　处：《中华风湿病学杂志》2008年第8期515-518,共4页Chinese Journal of Rheumatology

基　　金：国家自然科学基金重点项目（30530720）

摘　　要：目的通过研究类风湿关节炎（RA）患者外周血中可溶性CD147（sCD147）的表达水平及其与血脂水平相关性的分析，探讨sCD147在RA动脉粥样硬化中的作用。方法采用双抗体夹心ELISA方法分别检测RA、动脉粥样硬化性心脏病（CAHD）患者各36例及30名健康人血清中sCD147含量；测定RA患者病情活动度（DAS28），分析sCD147水平与其病情活动度的相关性；使用全自动生化分析仪测定RA患者血脂水平，分析患者血清中sCD147与血脂水平的相关性。结果RA患者血清中sCD147分子水平显著高于冠心病患者及健康对照，且病情高度活动RA组的sCD147含量显著高于病情低度及中度活动组（P均〈0．05）。总胆同醇（TC）升高组及甘油三酯（TG）升高组RA患者的TC、TG水平与其血清中sCD147含量呈正相关（r=-0．84，P〈0．05；r=0．87，P〈0．05），而1℃轻度升高及正常组或TG正常组患者的TC、TG水平则与其血清中sCD147含量无相关性（r=-0．41，P=-0．21；r=-0．14，P=-0．57；r=0．49，P=0．87）。低密度脂蛋门胆同醇（LDL-C）升高及轻度升高组患者的LDL—C水平与其血清中sCD147含量呈正相关（r=0．86，P〈0．05：r=0．81，P〈0．05），LDL—C正常组两者则无相关性（r=0．78，P=0．22）。RA患者高密度脂蛋白胆固醇（HDL-C）降低与否和其血清中sCD147水平无相关性（r=0．04，P=0．96；r=0．13，P=0．87）。结论RA患者体内sCD147分子可能参与了RA的发病，且与病情活动度有关。同时，其sCD147水平的升高还可能与其血清中血脂的异常有关。Objective To study the relationship between soluble CD147 （sCDI47） level in peripheral blood and serum lipid level and explore the effect of sCDI47 on atherosclerosis in rheumatoid arthritis （RA）. Methods The level of sCDI47 in 36 patients with RA, 36 patients with coronary artery disease （CAHD） and 30 healthy volunteers was detected by enzyme linked immunosorbent assay （ELISA） . The disease activity score （DAS28） in RA patients was evaluated and the correlation between sCD147 level and DAS28 score was analyzed. The serum lipid level of RA patients was detected by an automatic biochemical analyzer and the correlation between sCD147 level and serum lipid level was analyzed. Results The level of sCD147 in serum of RA patients was significantly higher than that in patients with CAHD and healthy volunteers, sCD147 level in the RA group with high DAS28 score was significantly higher than that with low or medium DAS28 score. In RA patients , elevated total cholesterol （TC） and triglyceride （TG） level was positively correlated with serum sCDI47 level （r=0.84, P〈0.05; r=0.87, P〈0.05; while slightly elevated , normal TC and normal TG had no correlation with serum sCDI47 level （r=0.41, P=0.21 ; r=0.14, P=0.57; r=0.49, P=0.87）. Elevated or slightly elevated LDL-C was positively correlated with serum sCDI47 level （r=0.86, P〈0.05; r=0.81, P〈0.05）, while no correlation could be found in the group with normal LDL-C level （r=0.78, P=0.22）. The high density lipoprotein-cholesterol （HDL-C） level decrease in RA patients had no correlation with serum sCDI47 level （r=0.04, P=0.96; r=0.13, P=0.87）. Conclusion sCDI47 may be involved in the pathogenesis of RA and associate with disease activity. Elevated sCD147 level may be associated with abnormal serum lipid in RA.

关 键 词：关节炎 类风湿 动脉粥样硬化 血脂 sCDl47 

分 类 号：R541.4[医药卫生—心血管疾病]