重叠感染SEN病毒对乙肝后肝硬化发展的影响  

Effect of SEN virus infection on the incidence of liver cirrhosis in patients with chronic hepatitis B

作　　者：叶彬[1] 潘发愤[1] 

机构地区：[1]温州医学院第一附属医院感染内科,浙江温州325000

出　　处：《温州医学院学报》2008年第4期351-352,355,共3页Journal of Wenzhou Medical College

基　　金：温州市科技局-温州医学院医药科技发展基金资助项目(LHZ02001)

摘　　要：目的:通过检测慢性乙型肝炎和乙肝肝硬化患者SEN病毒(SENV)的感染情况,了解重叠感染SENV对乙肝后肝硬化发展的影响。方法:采用巢式聚合酶链反应(nPCR)对148例慢性乙型肝炎患者、119例乙肝肝硬化患者和80例健康体检者进行SENV-D/H亚型的检测,并对部分阳性血清的PCR产物进行测序。结果:SENV-H在乙肝肝硬化患者血清中的检出率(为37.8%)高于慢性乙型肝炎患者(为26.4%),两者差异有显著性(P<0.05),而SENV-D的检出率分别为34.5%和30.4%,两者差异无显著性(P>0.05);健康体检者血清中,SENV-H和D的检出率分别为13.8%和16.3%,与上述两组患者相比差异有显著性(P<0.05);此外,在77例有输血史患者和190例无输血史患者血清中,SENV的总检出率分别为53.2%和55.8%,两者差异无显著性(P>0.05)。结论:重叠SENV-H感染可能对乙肝后肝硬化发展具有一定的影响,并且SENV的主要传播方式除输血外可能还存在其他途径。Objective： To investigate the influence of SEN virus infection on the incidence of liver cirrhosis in patients with chronic hepatitis B （CHB）. Methods： SENV-D and SENV-H DNA were detected in 148 cirrhosis patients with CHB、119 CHB patients and 80 healthy blood donors with nested- PCR. Some PCR products were sequenced. Results： By sequencing, the specificity of genotypespecific PCR was confirmed. The positive rates of SENV-H were obviously higher in cirrhosis patients with CHB than that in CHB patients（37.8% vs 26.4%, P〈0.05）. The prevalence of SENV-D/H viremia was significantly higher in patients with liver cirrhosis and CHB than that in healthy blood donors （SENV-D： 34.5%, 30.4% vs 16.3%; SENV-H： 37.8%, 26.4% vs 13.8%; P〈0.05）. No significant difference was found for SENV-H between patients with transfusion and ones without transfusion （53,2% vs 55.8%, P〉0.05）. Conclusion： Coinfection with SENV-H may influence the incidence of liver cirrhosis in patients with chronic hepatitis B, and transfusion is not single route of transmission of SEN virus.

关 键 词：SEN病毒 肝炎 乙型 慢性 肝硬化 输血 

分 类 号：R713.7[医药卫生—妇产科学]