痛泻要方对小鼠胃肠运动双向调节作用的研究  

Experimental Study on Dual-Direction Regulation of Tongxie Yaofang on Gastrointestinal Movement of Mice

作　　者：旺建伟[1] 赵文静[1] 历凯 赵雪莹[1] 安平[1] 

机构地区：[1]黑龙江中医药大学基础医学院,黑龙江哈尔滨150040 [2]哈尔滨市食品药品监督管理局,黑龙江哈尔滨150028

出　　处：《中国中医药信息杂志》2008年第8期32-34,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：哈尔滨市青年科学研究基金(2005AFQXJ039);黑龙江省中医管理局科研项目(ZY06-W05)

摘　　要：目的通过观察痛泻要方对小鼠不同机能状态胃肠运动的影响,研讨痛泻要方对胃肠运动的双向调节作用。方法采用大黄致小鼠腹泻模型、复方地芬诺酯致小鼠便秘模型及正常小鼠,观察不同剂量其对各组排稀便数量、次数、粪便直径及腹泻率、稀便率、稀便级、腹泻指数的影响;并通过对新斯的明致小鼠小肠推进功能亢进、阿托品致小鼠小肠推进功能抑制及正常小鼠小肠推进运动的影响,观察痛泻要方对小鼠小肠推进运动的调节作用。结果痛泻要方对小鼠腹泻模型、新斯的明致小鼠小肠推进功能亢进均有一定抑制胃肠运动作用;对小鼠便秘模型、阿托品致小鼠小肠推进功能抑制均有一定促进胃肠运动作用;对正常小鼠及其小肠推进运动均无明显作用。结论痛泻要方对小鼠不同机能状态胃肠运动有不同影响,具有双向调节作用,与中医方证相符、辨证论治相合。Objective To investigate the dual-direction regulation of Tongxie Yaofang on gastrointestinal movement by studying its effect on gastrointestinal movement of mice in various functional states. Methods Adopting diarrhea model induced by rhubarb, constipation model by compound diphenoxylate and normal mice, the effect of different doses of Tongxie Yaofang on loose stool quantity, degree, diameter, diarrhea rate, loose stool incidence rate, loose stool grade, diarrhea index of every group were observed. By esta blishing hyperfunction of small intestinal function in mice by neostigimine, inhibition of small intestinal function in mice by atropine sulfate and small intestinal propellant function in normal mice, the effect of Tongxie Yaofang on intestinal movement of mice were studied. Results Tongxie Yaofang could inhibit gastrointestinal movement of diarrhea model and hyperfunction of small intestinal function in mice by neostigimine. It could promote gastrointestinal movement of constipation model and inhibit small intestinal function in mice by atropine sulfate. But it had no obvious action on natural mice and its intestinal movement. Conclusions Tongxie Yaofang has dual-direction regulation on gastrointestinal movement of mice in various functional states, which has a good agreement with formula-syndrome in traditional Chinese medicine, conforms to treatment based on syndrome differentiation.

关 键 词：痛泻要方 胃肠运动 双向调节作用:肠易激综合征 小鼠 

分 类 号：R289.11[医药卫生—方剂学]