黄芩苷对实验性脑出血大鼠脑损伤的保护作用  

Neuroprotection of Baicalin on Brain Damage Following Experimental Intracerebral Hemorrhage in Rats

作　　者：刘平[1] 隗义双[1] 周乾坤[1] 余嗣明[1] 

机构地区：[1]安徽大学生命科学学院安徽省中药研究与开发重点实验室,安徽合肥230039

出　　处：《中国中医药信息杂志》2008年第4期34-35,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：安徽省教育厅自然科学基金资助(2004kj025)

摘　　要：目的观察黄芩苷对大鼠脑出血后脑组织损伤的影响,探讨其对大脑损伤保护机制。方法采用胶原酶法诱导脑出血模型,并随机分为假手术组、模型组及药物高、中、低剂量组,然后分别给予生理盐水、不同剂量黄芩苷灌胃,于3 d和7 d取材检测各组大鼠脑组织含水量及超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、一氧化氮合酶(NOS)等生化指标的变化。结果模型组大鼠脑组织含水量及MDA、NO、NOS水平显著高于假手术组,SOD值显著低于假手术组;药物高、中、低剂量组脑组织含水量及MDA、NO、NOS显著低于模型组,SOD值显著高于模型组。结论黄芩苷对实验性脑出血大鼠脑损伤的保护作用可能与其有效清除氧自由基、减轻自由基的神经毒性有关。Objective To observe the neuroprotection of Baicalin on brain damage following experimental intracerebral hemorrhage in rats. Methods Rat model of intracerebral hemorrhage was induced by collagenase method. The rats were randomly divided into sham operation control group, model group, high-, middle- and low- dose drug group, treated with different dose of Baicalin. The brain water content and the level of SOD, MDA, NO and NOS were measured at the third and seventh day after modeling repectively. Results Compared with the sham operation control group, the brain water content and the level of MDA, NO and NOS were significantly higher, and the level of SOD was significantly lower in model group. The brain water content and the level of MDA, NO and NOS were significantly lower, and the level of SOD was obviously higher in high-, middle- and low- dose Baicalin group than that in model group. Baicalin has evident protective effect on brain damage after experimental intracerebral hemorrhage in rats, which maybe related to the increase of SOD and decrease of MDA, NO and NOS.

关 键 词：黄芩苷 脑出血 脑含水量 神经保护作用 大鼠 

分 类 号：R285.5[医药卫生—中药学]