祛肝脂合剂对大鼠脂肪性肝炎的降脂保肝作用  

Antioxidation,Blood Lipid Reduction and Liver Protection of Quganzhi Mixture on Mice with Fatty Liver

作　　者：陈枫[1] 陈庄[1] 唐坤华[1] 李万平[2] 李世宁[3] 

机构地区：[1]泸州医学院附属医院,泸州646000 [2]泸州医学院药学院 [3]泸州医学院病理教研室

出　　处：《浙江中西医结合杂志》2008年第8期476-478,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:观察复方中药祛肝脂合剂的抗肝脂作用。方法:高脂饮食复制大鼠脂肪肝模型。选用雄性SD大鼠,空白对照组给以正常喂养,其余造模动物第12周随机分为模型组、祛肝脂合剂高、低剂量组和饮食控制组。4周后处死动物,心脏取血检查肝功、血脂及丙二醛(MDA)、超氧化物歧化酶(SOD)、谷光甘肽(GSH)和总抗氧化能力,取一部分肝组织做成10%的匀浆以检查肝脂水平,并取肝组织做病理检查。结果:祛肝脂合剂能减轻大鼠体重,降低转氨酶,升高白蛋白,降低肝脂及血脂水平,降低MDA,升高SOD、GSH,提高总抗氧化活力。结论:祛肝脂合剂能减轻脂肪肝,减轻肝脏损害。Objective： To observe the anti-fatty-liver effect of Quganzhi mixture, which is a decoction of Chinese traditional herbal formulas. Methods ： Male rats with fatty liver were induced by high - fat diet. The blank contrast group was fed normally. After 12 weeks, other rats were divided into the model group, the Quganzhi group with high dosage, the Quganzhi group with low dosage, and the diet control group. After 4 weeks, rats were killed and the blood samples were obtained from heart. The liver function, blood lipid, malondialdehyde （MDA）, superoxide dismutase （SOD）, glutathione （GSH） and total ani-oxidation capacity of blood were checked. The liver lipid levels of homogenous liver tissue were examined and the histological change of liver was analyzed. Results ： Quganzhi mixture can reduce body weight of rats, decrease aminotransferase, liver lipid, lipid level of blood and MDA, increase albumin, activities of SOD, GSH and total antioxidant capacity. Condusion：Quganzhi mixture can reduce fatty liver and liver damage.

关 键 词：大鼠 脂肪性肝炎 祛肝脂合剂 保肝作用 

分 类 号：R285.5[医药卫生—中药学]