滋补肝肾方药对慢性激怒应激大鼠下丘脑肝脏核糖体聚态的影响  

Effect on the rat with Chronically Enraged strees by nourishing Gan and Shen

作　　者：赵晓林[1] 李思[1] 贾漪涛[1] 佟晓旭[1] 赵京山[1] 高博[1] 陈永春[1] 王威[1] 

机构地区：[1]河北医科大学中西医结合基础理论研究室

出　　处：《中国中医基础医学杂志》1997年第5期28-30,33,共4页JOURNAL OF BASIC CHINESE MEDICINE

摘　　要：采用蔗糖密度梯度离心方法检测核糖体聚态以了解即刻蛋白质合成速率。结果显示慢性激怒应激使大鼠肝脏多聚核糖体解聚，提示蛋白质合成速率下降，加滋补肝肾方药组显示可拮抗该解聚，使多聚核糖体增加，表明可使肝脏即刻蛋白质合成速率增加，而加用疏肝理气方药和人参未见此效应。该应激状态及加用各组中药对下丘脑核糖体聚态无明显影响。By the method of sucrose density gradient centrifugation, polyribosome sedimentation pattern was investigated for finding out the rate of immediate protein synthesis. It was showed that chronically enrgaed stress caused polyribosome disaggregation in rat liver, which suggested lower rate of protein synthesis, the disagggregation could be resisted and polyribosome increased by administrating compound prescription of Nourishing Liver and Kidney.It indicated that the prescription might make the rate of immediate protein synthesis in liver increase, but there was no such effect presented in both groups of adding administration of compound prescription of Clear Liver and Regulating Qi or Panax Ginseng. No obvious effect of the stress status and adding administration of those Chinese herbal medicines mentioned above on polyribosome sedimentation pattern in the rat hypothalamus was be found. In this paper, the mechanisms of the effect of stress and adding administration of Chinese harbal medicine on the polyribosome gradient pattern in the both kinds of tissues(liver and hypothalamus) was conducted preliminary analysis.

关 键 词：中药 方剂 滋补肝肾方 多聚核糖体 下丘脑 肝脏 

分 类 号：R289.5[医药卫生—方剂学]