不同处方因素对替硝唑口腔生物黏附片性能的影响  

The influence of different formulation on the property of tinidazole buccal adhesive tablets

作　　者：郝吉福[1] 崔俊杰[2] 郭丰广[1] 孔志峰[1] 林小卫[1] 

机构地区：[1]泰山医学院药学院,山东泰安271000 [2]泰安市中医二院,山东泰安271000

出　　处：《中国医院药学杂志》2008年第11期891-893,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的:制备替硝唑口腔生物黏附片,并探讨不同处方因素对其性能的影响。方法:选择不同规格的Carbopol和HPMC作为黏膜黏附材料和缓释骨架材料,用直接粉末压片法制备替硝唑口腔黏附片。考察不同处方因素对黏附片的黏附力、体外溶胀率和体外释药速率等性能的影响。结果:随着Carbopol用量的增加,黏附片的黏附力、体外溶胀率呈现增加的趋势。通过体外释放度结果表明TNZ口腔黏附片存在着不同的释药机制。结论:不同规格和用量的Carbopol和HPMC影响黏附片的性能。OBJECTIVE To prepare tinidazole buccal adhesive tablets,and discuss the effect of different formulation on the property of the tablets. METHODS Selecting different types of Carbopol and HPMC as mucosity and sustained release matrix materials,using direct compression to prepare tablets,to review effect of different formulation on property of adhensive force,expanding rate, in vitro cumulating drug release of tablets. RESULTS With the increasing amount of Carbopol, adhensive force and expanding rate of tinidazole bueeal adhesive tablet present enhaneive trend. Through the results of in vitro release experiment showed different drug-release meehanism. CONCLUSION Different type and proportion of Carbopol and HPMC has significant influence on the property of tinidazole bueeal adhesive tablets.

关 键 词：替硝唑 口腔生物黏附片 性能 

分 类 号：R944[医药卫生—药剂学]