有效抗生育低剂量雷公藤糖浆对佐剂性关节炎大鼠免疫功能的影响  

The Influence of Tws on Immunological Function of Adjuvant Arthritis (AA) in Rats.

作　　者：路秀英[1] 修贺明[1] 徐铮[1] 李彬[1] 贾太和[1] 孙辉臣[1] 

机构地区：[1]白求恩国际和平医院,石家庄050082

出　　处：《中国计划生育学杂志》1997年第5期276-278,共3页Chinese Journal of Family Planning

基　　金：国家计划生育委员会资助

摘　　要：为全面观察具有抗生育作用的低剂量雷公藤糖浆对机体免疫功能的影响,在研究其对正常小鼠免疫功能影响这一早期工作基础上,观察其对佐剂性关节炎(adjuvant arthritis, AA)大鼠免疫功能的影响,实验结果表明,AA大鼠脾T淋巴细胞ConA诱导增殖反应和产生白细胞介素2(Interleukin2, IL-2)能力与正常对照组相比明显降低(P<0.01);AA大鼠腹腔巨噬细胞(macrophage, Mφ)产生白细胞介素1(interleukin 1, IL-)能力与正常对照组相比明显提高(P<0.01)。有效抗生育低剂量雷公藤糖浆对AA大鼠脾T淋巴细胞ConA诱导增殖反应和产生IL-2能力以及腹腔Mφ产生IL-1能力均无明显影响。上述结果提示有效抗生育作用的低剂量雷公藤糖浆对AA大鼠免疫功能无明显影响。The influence of low dose Tripterygium Wilfordii - syrup(TWs)with antifertility effect on immunologi-cal function of AA rats was studied. The results showed that the proliferative response of splenocytes to ConA-and the production of IL - 2 like substance of splenocytes in AA rats were significantly decreased as compared with normal control group. And there was no significant difference between AA group and TWs group ( P > 0.05). The production of IL - 1 like Substance of peritoneal macrophages of AA rats was significantly increased as compared with that of normal control group. Also there was no significant difference between AA group and TWs group(P>0.05) .The results indicated that low dose TWs with antifertility effect had no influence on immunological function of AA rats.

关 键 词：雷公藤糖浆 关节炎 免疫功能 

分 类 号：R979.5[医药卫生—药品] R684.305[医药卫生—药学]