正交实验优选复方磺胺嘧啶银乳膏剂基质  

Optimization of Compound Sulfadiazine Silver Cream Matrix Composition by Orthogonal Design Method and Evaluation of Safety

作　　者：余明莲[1] 王聪敏 郭月玲 刘畅 

机构地区：[1]北京军区总医院医疗东区药剂科,北京100026 [2]不详

出　　处：《解放军药学学报》2008年第4期317-319,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的优选复方磺胺嘧啶银乳膏剂的基质组成及工艺,考察安全性。方法以乳膏剂的稳定性及外观性状为考察指标,用正交设计法,以基质配比、乳化剂添加量和搅拌方式为可变因素,选用L9(34)表进行实验。结果最优的基质组成及工艺是:羊毛脂、液体石蜡、甘油、月桂氮酮、多羟基酰胺、聚多糖复合物,高剪切混合乳化机搅拌。结论按此法制备的乳膏剂符合中国药典2005年版有关软膏剂的规定。ABSTRACT：Aim To optimize compound sulfadiazine silver cream matrix composition and evaluate its salty. Methods The stability and appearance properties of the compound sulfadiazine silver cream were used as the target of evaluation. Orthogonal design method , matrix composition, added capacity of emulsifiers and ways of mixing were selected as variable factors and table L9（34） was used for the experiment. Results The optimum matrix com- position and process involved lanolin, liquid paraffin, glycerine, polyhydric amide and polysaccharide compounds. It was mixed for 10 minutes with a high-speed cutting emulsifier. Conclusion The cream prepared by this kind of composition and technology conforms to the stipulation of Chinese Pharmacopoeia （2005）.

关 键 词：正交设计法 复方磺胺嘧啶银乳膏 基质配比 乳膏剂 

分 类 号：TQ460.6[化学工程—制药化工]