无锡市城区20岁以上人群乙型肝炎病毒感染及免疫状况调查  

Study on the prevalence rate and immunity of hepatitis B virus infection among urban adults aged over 20 years in Wuxi, Jiangsu province

作　　者：钱燕华[1] 林玉娣[1] 沈洪兵[2] 董美华[1] 邓于[1] 缪小兰[1] 王旭雯[1] 顾静[1] 陈峰[2] 喻荣彬[2] 

机构地区：[1]江苏省无锡市疾病预防控制中心,214023 [2]南京医科大学流行病与卫生统计学系

出　　处：《中华流行病学杂志》2008年第8期783-786,共4页Chinese Journal of Epidemiology

基　　金：江苏省现代病原生物学重点实验室开放基金资助项目（1623）;江苏省预防医学科研基金资助项目（Y2006003）;2006年度无锡市社会发展科技指导性计划资助项目（CLZ00632）

摘　　要：目的对江苏省无锡市城区20岁以上自然人群HBV感染与乙型肝炎（乙肝）疫苗接种关系进行研究。方法按知情、自愿、随机的原则抽取无锡市20岁以上的自然人群3744名进行乙肝血清流行率和乙肝疫苗接种调查，采用ELISA和放射免疫分析法测定乙肝五项指标（HBsAg、抗-HHs、HBeAg、抗-HBe和抗-HBc）。结果3744名调查对象总HBV感染率经标化后为51．7％，HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc阳性率经标化后分别为4．5％、48．5％、0．3％、3．5％、51．4％。30岁以下人群HBsAg阳性率最低，分别为2．9％和2．6％。抗-HBc阳性率男性显著高于女性（P〈0．05），且随着年龄的增加而逐步升高（趋势X2=256．2，P〈0．001）。该人群乙肝疫苗标化接种率为17．6％，随着年龄的增加接种率迅速下降（P〈0．05）。接种疫苗人群的HBsAg阳性率和HBV感染率明显低于未接种疫苗人群、抗。HBs阳性率则高于未接种人群（P值均〈0．05）。结论成年人接种乙肝疫苗可以影响整个人群的HBV感染模式，在加强新生儿乙肝疫苗计划免疫同时，应进一步加强对成年人的乙肝疫苗免疫策略。Objective To study the relationship on the prevalence rate of hepatitis B virus （HBV） infection and hepatitis B vaccination in urban citizens aged over 20 years old which would led to the development of strategies on HBV control. Methods A total of 3744 subjects from general population were randomly selected in this study. Both ELISA and radio immunoassay were used to test five items of HBV infection, including HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc. Results The overall standardized infection rate of HBV was 51.7 %, and HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc were 4.5 %, 48.5%, 0.3%, 3.5% and 51.4%, respectively. The two lowest I-IBsAg positive rates were found in the groups under 30 years old （2.9%） and students （2.6 % ）. Anti-HBc rate among men was significantly higher than seen in women （P〈0.05）, and showing a trend of increase with age （Z2 for trend-256.2, P 〈 0. 001 ）. The standardized rates of liB vaccination in this population was 17.6 % and decreasing rapidly with age （P〈0.05）. People who had been vaccinated had both lower rates of I-IBsAg and HBV infection but higher rate of anti-HBs than those who had not （P〈 0.05）. Conclusion HB vaccination in adults showed a reducing rate of I-IBV infection in the general population. Together with the enhancement of expanded program on immunization towards HB vaccination in neonates, much attention should be paid to HB vaccination in adults.

关 键 词：乙型肝炎病毒 自然人群 免疫状况 

分 类 号：R51[医药卫生—内科学]