动脉硬化平滑肌细胞增殖和凋亡及其调节  

Regulation of Proliferation and Apoptosis of Smooth Muscle Cell in Atherosclerosis

作　　者：杨和平[1] 杨永宗[1] 

机构地区：[1]衡阳医学院分子生物学研究中心,衡阳421001

出　　处：《高技术通讯》1997年第8期49-52,共4页Chinese High Technology Letters

摘　　要：为阐明动脉粥样硬化（AS）斑块发展与稳定的内在机制，围绕动脉增生内膜、AS斑块内平滑肌细胞（SMC）增殖和凋亡密切相关的即刻早期基因（c－fos、c－jun、c－myc）和相关基因（p53、bc1－2、c－sis）表达失衡和重调这一中心展开研究，提出血管SMC增殖和凋亡是决定AS斑块发展的关键环节。In order to expound the mechanism of progression and stability of atherosclerotoic plaques,the extensive study about expression imbalance and deregulation of immediate early genes(c-fos,c-jun and c-myc) and relative genes (p53, bcl-2 and c-sis)which are closely related to proliferation and apoptosis of smooth muscle cells (SMCs) in atherosclerotic plaque has been made. It is pointed out that it is the proliferation and apoptosis of SMC that determine the progression of atherosclerotic plaques.

关 键 词：动脉粥样硬化 平滑肌细胞 细胞增殖 细胞凋亡 调节 

分 类 号：R543.5[医药卫生—心血管疾病]