阻塞性睡眠呼吸暂停低通气综合征患者日间嗜睡与夜间血氧的相关研究  

Daytime Sleepiness and Nocturnal Hypoxemia in Obstructive Sleep Apnea-hypopnea Syndrome Patients

作　　者：孔德磊[1] 王玮[1] 康健[1] 苏新明[1] 代兵[1] 

机构地区：[1]中国医科大学附属第一医院呼吸内科,沈阳110001

出　　处：《中国医科大学学报》2008年第4期539-541,共3页Journal of China Medical University

基　　金：教育部博士学科点专项基金资助项目(20060159023)

摘　　要：目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者日间嗜睡与夜间低氧血症的关系。方法90例OSAHS患者根据嗜睡评分分组,比较嗜睡组与非嗜睡组的一般状况和夜间多导睡眠监测参数,并将日间嗜睡评分与夜间多导睡眠监测参数进行相关分析。结果嗜睡组与非嗜睡组相比,嗜睡评分[(16.37±4.19)分vs(2.7±2.26)分,P<0.01]、睡眠呼吸暂停低通气指数[(44.81±22.04)次/hvs(20.24±13.56)次/h,P<0.05]、氧减指数[(49.87±24.03)次/hvs(24.88±14.22)次/h,P<0.05]高于非嗜睡组,最低血氧饱和度[(68.21±10.93)%vs(77±6.32)%,P<0.05]低于非嗜睡组。多元逐步回归日间嗜睡评分仅与氧减指数相关(R2=0.303,P<0.05)。结论OSAHS患者日间嗜睡与氧减指数密切相关,夜间低氧血症是OSAHS患者出现日间嗜睡的主要原因。Objective To evaluate the relationship between excessive daytime sleepiness and nocturnal hypoxeamia. Methods Polysomnography was carried out and the Epworth Sleepiness Scale （ESS） was evaluated in ninety OSAHS patients, who were, then, divided into two groups according to ESS, and multiple stepwise regression was used. Results Patients with sleepiness had higher ESS Scale （ESS Scale 16.37±4.19 and 2.7±2.26,respeetively,P 〈 0.001 ）,AHI [ （44.81±22.04）/h vs （20.24±13.56）/h,P 〈 0.05] and nocturnal oxygen saturation index [ （49.87±24.03）/h vs （24.88±14.22）/h, P 〈 0.05 ], and had lower nadir nocturnal oxygen saturation [ （68.21±10.93）% vs （77±6.32）%, P 〈 0.05 ] than the controls. Multiple stepwise regression showed that ESS was correlated with nocturnal oxygen saturation index （R^2=0.303, P 〈 0.05）. Conclusion ESS is closely correlated with nocturnal oxygen saturation index in OSAHS patients. Nocturnal hypoxaemia can be a major determinant of excessive daytime sleepiness in patients with obstructive sleep apnea-hypopnea syndrome.patients with obstructive sleep apnea-hypopnea syndrome.

关 键 词：日间嗜睡 嗜睡评分 夜间低氧血症 阻塞性睡眠呼吸暂停低通气综合征 

分 类 号：R563.9[医药卫生—呼吸系统]