硫酸镁对靶控异丙酚、瑞芬太尼用量及术后疼痛的影响  

Effect of Magnesium Sulfate on the Amount of Propofol Given by TCI and Remifentanil Requirement and on Postoperative Pain Relief

作　　者：孙喜家[1] 虞建刚[1] 王俊科[1] 

机构地区：[1]中国医科大学附属第一医院麻醉科,沈阳110001

出　　处：《中国医科大学学报》2008年第4期548-550,共3页Journal of China Medical University

摘　　要：目的探讨硫酸镁对术中靶控异丙酚、瑞芬太尼用量以及术后疼痛的影响。方法采用随机、对照、双盲方法将ASAⅠ～Ⅱ级择期行开腹手术的妇科患者40例,随机分为硫酸镁组(M组)和对照组(C组),每组20例。比较两组患者手术开始后每30min各时刻的异丙酚、瑞芬太尼用量及总用量,并对术后清醒即刻、术后30min、60min的疼痛情况进行VAS评分。结果手术开始后各时点的异丙酚、瑞芬太尼用药量M组低于C组(P<0.05),总用量M组低于C组(P<0.05)。患者术后镇痛评分M组低于C组(P<0.05),术后首次应用镇痛药的时间M组较C组明显延迟(P<0.01)。结论静脉应用硫酸镁可以降低术中异丙酚及瑞芬太尼的用量,减少术后镇痛药的用药量和首次用药时间。硫酸镁可以作为一种辅助性药物应用于临床麻醉。Objective To study the effects of magnesium suliate on the amount of propofol given by TCI and remifentanil requirement and on postoperative pain relief. Methods In a randomized double-blinded and placebo-controUed study,forty women （ASA Ⅰ -Ⅱ ） undergoing abdominal surgery were randomly divided into two groups：the magnesium sulfate group （M group） and the control group （C group）. The amounts of propofol and remifentanil were recorded every 30min from the start of the surgery. The postoperative pain rehef was assessed using visual analog scale （VAS） and the time was measured from the end of surgery to the first time when anesthetic was used. Results The consumption of propofol and remifentanil was lower in group M （P 〈 0.05 ）.The total consumption was also lower in group M （P 〈 0.05 ）. The amount of remifentanil was significantly reduced in both groups. The VAS score was lower and the time when anesthetic was first used was longer in group M. Conclusion Intravenous administration of magnesium sulfate reduces propofol given by TCI and remlfentanil infusion requirement, and inhibits the postoperative pain. Magnesium sulfate could be an adjuvant to preoperative management in anesthesia.

关 键 词：硫酸镁 二异丙酚 瑞芬太尼 疼痛 

分 类 号：R614[医药卫生—麻醉学]