女性迟发性痤疮患者血清性激素水平的研究  

Study on Serum Levels of Sex Hormones in the Follicular Phase of Menstrual Cycle in Late-onset Female Patients with Acne Vulgaris

作　　者：于中蛟[1] 王桂平[1] 薛承岩[1] 陆洁[1] 段昕所[1] 孙立新[1] 

机构地区：[1]承德医学院附属医院皮肤科,河北承德067000

出　　处：《现代检验医学杂志》2008年第4期86-87,共2页Journal of Modern Laboratory Medicine

基　　金：2005年承德市科学技术研究与发展计划(编号:200521037)

摘　　要：目的探讨女性迟发性痤疮患者体内性激素水平的改变。方法采用电化学发光免疫分析(ECLI)法对60例女性迟发性痤疮患者卵泡期血清六项性激素水平进行检测,并以40例相应年龄段的正常女性作对照。结果女性迟发性痤疮患者血清睾酮水平较相应年龄的正常对照组显著升高(P<0.01);睾酮/雌二醇与对照组相比显著升高(P<0.05);而雌二醇、孕酮、促卵泡素、黄体生成素、催乳素与对照组相比均无显著性差异(P>0.05)。结论女性迟发性痤疮发病的主要原因可能与雄激素分泌增多有关。Objective To investigate the levels of serum sex hormones changes in late-onset female patients with acne vulgaris. Methods The serum levels of luteinizing hormone （LH）,follicle-stimulating hormone （FSH）,estradion2 （E2）, testosterone （T）,progesterone （P） and prolactin （PRL） in the follicular phase of the menstrual cycle were measureded with electro-chemilumlnescence immunoassay （ECLI） in 60 late-onset female patients with ache vulgaris,40 cases healthy post adolescent female subjects over the age of 25 years old were selected as controls. Results The serum T levels of the late-onset female patients with ache were significantly higher than that of the normal controls （P〈0. 0l）;no significant difference was found in the serum levels of E2,P,FSH, PRL and LH between the late-onset female patients with acne and that of the controls. The ratio of T/E2 was significantly higher in the late-onset female patients with ache vulgaris than that of the controls （P〈0. 05）. Conclusion The level of serum T may be increased in female patients with late-onset acne vulgaris.

关 键 词：女性 寻常痤疮 卵泡期 性激素 电化学发光免疫分析 

分 类 号：R758.733[医药卫生—皮肤病学与性病学] Q579.1[医药卫生—临床医学]