持续高容量血液滤过对急性呼吸窘迫综合征患者呼吸力学和血流动力学的影响  

The influence of continuous high volume hemoffitration on respiratory mechanics and hemodynamics in patients with acute respiratory distress syndrome

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作  者:杨君[1] 解建[1] 李涛[1] 

机构地区:[1]山东大学附属千佛山医院ICU,济南250014

出  处:《中国医师进修杂志(内科版)》2008年第8期27-29,共3页Chinese Journal of Postgraduates of Medicine

摘  要:目的探讨持续高容量血液滤过(HVHF)对急性呼吸窘迫综合征(ARDS)患者呼吸力学和血流动力学的影响。方法选择由各种病因导致的ARDS患者22例,全部病例均在呼吸机支持下给予48h的HVHF,在HVHF治疗前及治疗后12、24和48h监测并记录气道峰压、动态肺顺应性、平均肺动脉压(MPAP)、肺动脉楔压(PAwP)、心排血量(CO)、外周循环阻力(SVR)、肺循环阻力(PVR)和血气分析。结果HVHF治疗后48h,气道峰压、动态肺顺应性、MPAP、PAWP、CO、PVR、SVR、氧合指数分别为(31.32±2.23)cmH2O(1cmH2O:0.098kPa)、(26.18±3.54)ml/cmH2O、(32.05±1.99)mmHg(1mmHg=0.133kPa)、(12.14±1.78)mmHg。(6.18±0.91)L/min、(194.95±11.51)dyn·s·cm^-5、(1071.55±66.50)dyn·s·cm^-5、(220.41±21.41)mmHg,均得到明显改善(P〈0.01)。结论HVHF可明显改善ARDS患者的呼吸力学和血流动力学。Objective To investigate the effect of continuous high volume hemofi/tration (HVHF) on respiratory mechanics and hemodynamics in patients with acute respiratory distress syndrome (ARDS). Methods Twenty-two patients with ARDS who received mechanical ventilation were treated with HVHF(6 L/h ) for 48 hours.The cardiac, output (CO), systemic vascular resistance (SVR), pulmonary vascular resis- tance (PVR), metal pulmonary arterial pressure (MPAP) , pulmonary artery wedge pressure (PAWP), PaO2/FiO2 and peak airway pressure(Ppeak)was measured. Results The Ppeak, Cdyn, MPAP, PAWP, CO, PVR, SVR and PaO2/FiO2 after HVHF at 48 hours was (31.32 ± 2.23 )cm H2O, (26.18 ± 3.54)ml/cm H2O, (32.05± 1.99)mm Hg,(12.14 ±1.78)mm Hg, (6.18 ± 0.91)L/min, and (194.95 ±11.51)dyn·s ·cm^-5, (1071.55 ±66.50)dyn·s·cm^-5, (220.41 ±21.41)mm Hg, respectively (P〈0.01). Conclusion HVHF shows significantly beneficial effects on respiratory mechanics and hemodynamics of ARDS.

关 键 词:血液滤过 呼吸窘迫综合征 成人 呼吸力学 血液动力学现象 

分 类 号:R563.8[医药卫生—呼吸系统] R459.5[医药卫生—内科学]

 

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