苯那普利对原发性肾病综合征的临床作用及对血清瘦素的影响  

Effect of benazepril towards primary nephrotic syndrome and the influence for sero-leptin

作　　者：黄联继[1] 戴朝福[1] 杨锦华[1] 肖云武[2] 郭树清[1] 

机构地区：[1]广东省韶关学院医学院附属新华医院内儿科教研室,512026 [2]湖南省湘潭职业技术学院医学院

出　　处：《中国实用医药》2008年第21期21-23,共3页China Practical Medicine

摘　　要：目的观察苯那普利(Benazepril)与泼尼松合用治疗原发性肾病综合征(单纯型PNS)的临床疗效及治疗前后血清瘦素(Ieptin,LP)水平的变化。方法选择PNS(单纯型)患儿60例,按照随机数字表法分为治疗组32例和对照组28例,对照组采用泼尼松(Predisone)中疗程法,治疗组在对照组基础上加用苯那普利(Benazepril)5岁以下3mg/d,7岁以下5mg,10岁以下7mg,1次/d,研究观察疗程为12周,两组均在治疗前、后4、8、12周的临床疗效及蛋白尿、血浆白蛋白(AIb)、血胆固醇(TC)及LP指标的变化,治疗结束后继续随访2年进行两组病情反复或复发率的观察。结果治疗组临床疗效优于对照组(P<0.05),病情反复及复发率治疗组明显低于对照组(P<0.05),LP变化与尿蛋白及TC呈负相关),与血浆白蛋白(AIb)呈正相关(P<0.01和P<0.05)。结论苯那普利(Benazepril)与泼尼松合用可稳定因泼尼松引起的高血压,改善肾血流量和肾滤过膜功能,增强临床疗效,缩短最佳有效疗程时间,稳定疗效作用,有效降低LP水平,减少糖皮质激素副反应的作用。Objective To observe the effect of their treatment and the change, Benazepril was combined with Predisone in use for curing primary nephrotic syndrome and the change of Sero-Leptin from beginning to end. Methods According to numbers chosen at random,60 PNS patients were chosen and divided into the treatment group（ 32 examples）and the control group（ 28 examples）, Prednisone was administered in routine regimen to all the patients, Benazepril was given to the treatment group, 3 mg/d dosage was given to the patients less than 5 years old,5 mg/d to the patients less than 7 years old and 7 mg/d to the patients less than 10 years old. The clinical research observation course was 12 W . In all the cases before starting the course and at the end of 4,8,12 weeks during the course, the change of albuminuria, the plasma-albumin （ AIb）, the total cholesterol （TC） and the LP level was tested and observed. After the clinical treatment had ended, a two-year follow-up was carried on about progression of the disease as well as the recurrence rate. Results The clinical curative effect of the treatment group was superior to the control group significantly（P 〈0. 05 ）. The recurrence rate of disease in the treatment group was lower than that of the control group obviously （ P 〈 0. 05 ）. Not only the albuminuria, but also TC correlates inversely to the LP level change （P 〈 0. 01 ）, however, albuminuria presented positive correlation with the plasma-albumin （P 〈 0. 05 ）. Conclusion Combination Benazepril with Prednisone can stabilize hypertension caused by Prednisone,improving renal blood flow and the function of the kidney filter membrane, strengthening clinical curative effect, shortening the time of therapy greatly, keeping the therapeutic effect, lowering the LP level effectively, reducing the side reaction of glucocorticoid.

关 键 词：苯那普利 原发性肾病综合征 瘦素 泼尼松 

分 类 号：R692.3[医药卫生—泌尿科学]