新疆一枝蒿化学成分的研究  

Chemical constituents from herb of Artemisia rupestris

作　　者：杨建波[1] 吉腾飞[1] 宋卫霞[1] 王爱国[1] 苏亚伦[1] 

机构地区：[1]中国医学科学院中国协和医科大学药物研究所,北京100050

出　　处：《中草药》2008年第8期1125-1127,共3页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(20572134)

摘　　要：目的研究新疆一枝蒿Artemisia rupestris全草的化学成分。方法采用硅胶、聚酰胺和Sephadex LH-20等方法进行分离纯化,采用光谱分析和理化常数对照等方法对所得化合物进行结构鉴定。结果从新疆一枝蒿的醋酸乙酯部分分离得到6个化合物,分别是:6-去甲氧基-4′-O-甲基茵陈色原酮-7-O-[6″-乙酰氧基)-β-D-葡萄糖苷(6-demethoxy-4′-O-methylcapillarisin-7-O-(6″-acetoxy)-β-D-glucopyranoside,]、6-去甲氧基-4′-O-甲基茵陈色原酮-7-O-β-D-葡萄糖苷(6-demethoxy-4′-O-methylcapillarisin-7-O-β-D-glucopyranoside,)、刺槐素-7-O-β-D-葡萄糖苷(acacetin-7-O-β-D-glucopyranoside,)、对羟基苯甲酸(p-hydroxybenzoic acid,)、一枝蒿酮酸(rupestonic acid,)、胡萝卜苷(daucosterol,)。结论其中化合物为新化合物,命名为一枝蒿苷A(rupestriside A),化合物～为首次从该植物中分离得到。Objective To study the chemical constituents from herb of Arternisia rupestris. Methods The chemical constituents were isolated by column chromatography on silica gel, polyamide, and Sephadex LH-20. Their structures were elucidated on the basis of spectral analysis. Results Six compounds were isolated from this plant and their structures were identified as 6-demethoxy-4＇-O-methylcapillarisin-7-O- （6＂-acetoxy）-β-D-glucopyranoside （ I ）, 6-demethoxy-4＇-O-methylcapillarisin-7-O-β-D-glucopYranoside （ II ）, acacetin-7-O-βD-glucopyranoside （ I ）, p-hydroxybenzoic acid （ IV ）, rupestonic acid （ Y ）, and daucosterol （VI）. Conclusion Compound I is a new compound named as rupestriside A and compounds I -- N are isolated from this plant for the first time.

关 键 词：蒿属 新疆一枝蒿 化学成分 

分 类 号：R284.1[医药卫生—中药学]