N-甲基-2-吡啶乙胺二盐酸盐的合成  

Preparation of N-methyl-2-(2-pyridyl)ethylamine dihydrochloride

作　　者：叶瑾亮 张小春 陈伟健 

机构地区：[1]广东省化学工业公共试验室广东省石油化工研究院,广东广州510665

出　　处：《广东化工》2008年第8期22-23,共2页Guangdong Chemical Industry

摘　　要：以2-乙烯基吡啶为起始原料,以水为溶剂,在回流状态下与甲胺乙酸盐进行加成反应,得到N-甲基-2-吡啶乙胺(倍他司汀),产率大于88%。将N-甲基-2-吡啶乙胺溶解于无水异丙醇中,通入干燥氯化氢气体,得到N-甲基-2-吡啶乙胺二盐酸盐,产率大于95%,反应总产率大于80%。并通过IR和HNMR,对中间体和目标产物进行了表征。Methyl amine acetate was added to 2-vinylpyridine in water under reflux, giving N-methyl-2-（2-pyridyl）ethylamine（betahistine） in more than 88 % yield, and the yielded compound was added with dry gaseous hydrochloride in absolute isopropyl alcohol to get N-methyl-2-（2-pyridyl）ethylamine dihydrochloride in a I yield of above 95 %, and the total yield was more than 80 %. The intermediate and titled compound were characterized by IR and HNMR.

关 键 词：N-甲基-2-吡啶乙胺二盐酸盐 2-乙烯基吡啶 盐酸倍他司汀 合成 

分 类 号：TQ331.46[化学工程—橡胶工业] TQ465.3