补肾益心片对男性高血压病患者勃起功能障碍的临床观察  

Clinical Research of Bushenyixin Tablet for Erectile Dysfunction with Hypertension

作　　者：薛峥[1] 陈宏珪[2] 吴伟[2] 

机构地区：[1]广州市中医院,广东广州510130 [2]广州中医药大学第一附属医院,广东广州510000

出　　处：《福建中医学院学报》2008年第4期7-8,23,共3页Journal of Fujian College of Traditional Chinese Medicine

摘　　要：目的补肾益心片对男性高血压病患者勃起功能障碍的临床疗效观察及作用机理。方法按照随机对照盲法的原则,将54例男性高血压病勃起功能障碍(ED)患者按21∶随机分成治疗组和对照组。两组都参照HOT研究方案进行基础降压治疗,治疗组加用补肾益心片,观察8周后的临床疗效,并测定T、PRL、E2,同时观察患者的不良反应。结果治疗后治疗组与对照组血压均明显下降,治疗组明显改善勃起功能指数和每月性交次数,而对照组无改善甚至有所降低(P<0.01或P<0.05);治疗组能明显改善临床症状,其在改善临床症状的总有效率是91.66%,优于对照组的55.56%(P<0.01);另外治疗组的内分泌各项指标在治疗后均有改善,但只有E2具有统计学意义。结论补肾益心片可以改善男性高血压病患者勃起功能障碍,疗效确切,其机理可能是通过调节内分泌、提高神经介质的传递功能、干预动脉粥样硬化、改善血管内皮功能、改善症状、提高生活质量等实现其临床疗效。Objective To observe the effect of Bushenyixin tablet on erectile dysfunction （ED） with Hypertension and explore its mechanism. Methods 54 patients were divided randomly into the treat group （n=36） and the control group （n=lS）. Two groups had carried out based antihypertensive treatment, while added Bushenyixin tablet in treat group. The curative effects of two groups were evaluated, and the changes of T, PRL, E2 and the side effects were observed after 8 weeks. Results The BP of two groups were all droped obviously. The ED index and the time of sexual intercourse per month of treat group had been improved greatly, and the total effective rate was 91.66% in treat group and 55.56% in control group. These differences above had statistics meaning （P〈0.01 or P〈0.05）. Conclusion Bushenyixin tablet can be used to treat ED with hypertension and has good effect.

关 键 词：补肾益心片 高血压病 勃起功能障碍 

分 类 号：R259[医药卫生—中西医结合]