复方刺蒺藜苷对慢性轻度不可预见性应激抑郁模型鼠行为学的影响  

Effect of Compound Tribuloside on Behavior of Chronic Stress Depression Rats

作　　者：沈双宏[1] 沈晓东 胡随瑜[3] 杜建[1] 谭春江[1] 

机构地区：[1]福建中医学院,福建福州350108 [2]黑龙江省农垦第二医院,黑龙江佳木斯154007 [3]中南大学湘雅医院中西医结合研究所,湖南长沙410008

出　　处：《福建中医学院学报》2008年第4期13-15,43,共4页Journal of Fujian College of Traditional Chinese Medicine

基　　金：国家"十五"科技攻关项目资助课题(2001BA701A22);福建省科技厅青年创新基金(2006F3062)

摘　　要：目的观察复方刺蒺藜苷对慢性轻度不可预见性应激抑郁模型大鼠行为学的影响。方法采用慢性轻度不可预见性应激加孤养建立大鼠抑郁模型,通过敞箱实验、糖水消耗实验等观察抑郁模型大鼠行为学改变。结果慢性应激抑郁大鼠体重增长缓慢;蔗糖溶液消耗量减少;敞箱实验中水平穿越格数、竖立次数、理毛时间有减少,中央格停留时间、粪便粒数均有增加,情绪性行为得分增加。复方刺蒺藜苷和氟西汀可改善大鼠行为学变化。结论复方刺蒺藜苷能明显改善抑郁动物的各项行为学指标,具有抗抑郁作用。Objective To observe the effect of compound tribuloside on behavior of chronic stress depression rats. Methods All rats except the control group were singly housed and exposed an unpredicted sequence of mild stressor. The behaviors of rats were detected by open-field test. Results The weight of rats in model group significantly decreased compared with the control group. Squares crossed, rears, and grooming reduced in open-field test, while the time of staying in central square and defecation were increased. Fluoxetine or compound tribuloside can significantly improve behavioral disorder. Conclusion Compound tribuloside can improve behavior of depression model rats and possess antidepressant effect.

关 键 词：复方刺蒺藜苷 慢性应激:抑郁模型 

分 类 号：R285.6[医药卫生—中药学]