健心颗粒对慢性心衰大鼠血流动力学及内皮素的影响  

Effect of Jianxin Granule on Hemodynamics,ET-1 and ALD in Chronic Heart Failure Rats

作　　者：严锦贤[1] 范德东[1] 蔡晶[2] 陈美华[1] 林求诚[3] 

机构地区：[1]福建中医学院附属第二人民医院,福建福州350003 [2]福建中医学院,福建福州350018 [3]福建省中医药研究院,福建福州350003

出　　处：《福建中医学院学报》2008年第4期19-20,43,共3页Journal of Fujian College of Traditional Chinese Medicine

基　　金：福建省卫生厅重点立项课题(No.605)

摘　　要：目的主要探讨健心颗粒对自发性高血压大鼠(SHR)慢性心力衰竭(CHF)时的作用及机理。方法观察健心颗粒对15周龄SHR大鼠的血流动力学及血浆内皮素(ET-1)的影响。结果健心颗粒能提高左室内压峰值(LVSP)、左室内压力最大变化速率(LV+dp/dtmax),降低左室舒张末压(LVEDP),降低血浆内ET-1水平。结论健心颗粒能改善SHR大鼠的心脏收缩与舒张功能,抑制血浆内ET-1,进而抑制心肌肥大,逆转心室重构。Objective To investigate the mechanism of the Jianxin granule in treating chronic heart failure （CHF） in spontaneously hypertensive rats （SHR）. Methods The changes of hemodynamics （LVSP, LVEDP, ±dp/dtmax） and neuroendocrine indicators （ET-1,ALD） were observed in SHR rats treated with Jianxin granule. Results In high dose and middle dose groups of Jianxin granule, the LVSP and ±dp/dtmax were increased remarkably and LVEDP decreased compared with the control group, and the level of ET-1 reduced significantly. Conclusion Jianxin granule could significantly improve the myocardial contractility and relaxation in SHR and reduce the level of ET-1 to prevent ventricular remodeling.

关 键 词：健心颗粒 慢性心袁 自发性高血压大鼠 

分 类 号：R285.6[医药卫生—中药学]