N-苯甲酰基苯并异噻唑-3-酮硫代甲酰胺类化合物的合成及生物活性  

Synthesis and Antibacterial Activity of N-Benzoyl-3-oxobenzo[d]isothiazole-2(3H)-carbothioamide

作　　者：王向辉[1] 杨建新[1] 贺永宁[1] 盘茂东[1] 林强[1] 

机构地区：[1]海南大学热带生物资源教育部重点实验室,海南海口570228

出　　处：《精细化工》2008年第8期771-774,共4页Fine Chemicals

基　　金：海南省自然科学基金资助项目(编号:20503)~~

摘　　要：通过1,2-苯并异噻唑啉-2（3H）-酮和硫代异氰酸苯甲酸酐类化合物反应,合成了7种N-苯甲酰基苯并异噻唑-3-酮硫代甲酰胺类化合物,用IR、MS、^1HNMR、^13CNMR对其结构进行了表征;活性测试表明,浓度为0.005mol/L的该类化合物溶液对鳗孤菌、拟态孤菌、溶藻弧菌、大肠杆菌和嗜水性单胞菌的抑菌率达40.5%～100%。Seven N-benzoyl-3-oxobenzo[d]isothiazole-2（3H）-carbothioamide derivatives were synthesized through the reaction of benzoyl isothiocyanate compounds and 1,2-benzisothiazol-2（3H）-one,and their antimicrobial activity was evaluated.Structures of the new compounds were confirmed by IR,MS,^1HNMR and ^13CNMR.Assayed in vitro for their antimicrobial activity against Vibrio anguillarum,Vibrio mimicus,Vibro alginolyicus,Escherichia coli and Aeromonas hydrophila,the inhibition of solutions of the compounds（0.005 mol/L） against bacteria ranges from 40.5% to 100%.

关 键 词：1 2-苯并异噻唑啉-2(3H)-酮 硫代异氰酸苯甲酸酐 杀菌剂 医药与日化原料 

分 类 号：TQ572.42[化学工程—精细化工]