一种基因芯片检测仪样机的研制及可靠性分析  

Development of a Prototypical Tester with Gene Chips to Simulate Robot's Motion and Analysis of Its Reliability

作　　者：王丹[1] 贾丽娜[1] 王晓光[1] 李明[1] 

机构地区：[1]东北大学机械工程与自动化学院,辽宁沈阳110004

出　　处：《东北大学学报（自然科学版）》2008年第8期1172-1175,共4页Journal of Northeastern University(Natural Science)

基　　金：辽宁省自然科学基金资助项目(20062029)

摘　　要：根据核酸扩增基因芯片杂交检测的原理设计了一个能够集扩增、杂交、检测于一体的新型检测仪的主体结构.利用大型仿真软件ADAMS对检测仪的主体机器人虚拟样机进行了运动学仿真,得到基因芯片的位移-时间和速度-时间曲线.应用机构运动可靠性原理对主体机器人的运动可靠性进行了分析,计算了主体机器人的运动精度.结果表明,无论考虑横向误差还是纵向误差,检测仪都具有良好的运动精度,从而证明了样机的可行性.The prototype of a new tester was proposed and conceptually designed on the basis of the hybridization of gene chips resulting from nucleic acid amplification, which integrates the effects of amplification, hybridization, cleaning and testing together. The simulation software ADAMS was applied to the tester to kinematically simulate the virtual prototype of a robot which is just the core part of the tester. The time response curves of robot＇ s swinging arms with gene chip fitted together were then obtained. By means of the principle of kinematic reliability of mechanisms, the reliability of the robot＇s motion was analyzed with its kinematic precision calculated. The results indicated that the tester can provide well the kinematic precision for either transverse or longitudinal motion of robot, thus verifying the feasibility of the prototypical tester.

关 键 词：基因芯片 杂交 PCR扩增 主体机器人 仿真 可靠度 

分 类 号：TP24[自动化与计算机技术—检测技术与自动化装置]