腰椎间盘突出症患者血浆CGRP升高的机制探讨  

Study on the Mechanism of the Increasing of Plasma CGRP in Patients with Lumbar Disc Herniation

作　　者：曾铁功[1] 张朝跃[2] 沈合群 

机构地区：[1]邵阳医学高等专科学校,湖南邵阳422000 [2]中南大学湘雅三医院,湖南长沙410013 [3]湖南省邵阳市中心医院,湖南邵阳422000

出　　处：《医学临床研究》2008年第8期1384-1386,共3页Journal of Clinical Research

摘　　要：【目的】探讨腰椎间盘突出症患者血浆降钙素基因相关肽(CGRP)水平及其调节机制。【方法】实验分为对照组、腰椎间盘突出症患者组,免疫化学法、RT-PCR法测定患者血浆血红素氧合酶-1(HO-1)、一氧化碳(CO)、环磷酸乌苷(cGMP)、CGRP的表达量。【结果】腰椎间盘突出症患者血浆的HO-1、CO、cGMP和CGRP显著高于对照组(P<0.05),且HO-1与CO、CO与cGMP、cGMP与CGRP的表达变化呈正相关(P<0.05)。【结论】腰椎间盘突出症患者血浆CGRP升高,通过HO-1-CO-cGMP途径促进CGRP的合成和释放可能是其血浆CGRP升高的调节机制之一。[Objective] To study the mechanism of calcitonin gene related peptide （CGRP） releasing in patients with lumbar disc herniation（LDH）. [Methods]The patients were randomly divided into control and LDH groups （n = 40, ineach）. Heme oxygenase-1（HO-1）, carbon monoxide（CO）, cGMP and CGRP in plasma were detected by immunoassay and RT-PCR, respectively. [Results]Compared with control group, HO-1, CO, cGMP and CGRP significantly increased in LDH group, and the increasing of HO-1 and CO, CO and cGMP, cGMP and CGRP were positive correlation （ P 〈0.05）. [Conclusion]Plasma CGRP in patients with LDH significantly increases, and HO-1-CO-cGMP pathway may be one of its mechanisms.

关 键 词：腰椎 椎间盘移位 降钙素基因相关肽/血液 

分 类 号：R681.53[医药卫生—骨科学]