山莨菪碱慢性给药对自发性高血压大鼠主动脉功能及形态的影响  

Influence of anisodamine chronic administration on the vascular function and morphology spontaneously hypertensive rats

作　　者：王烈[1] 郭敬[1] 陈红[2] 黎成金[1] 

机构地区：[1]福州总医院南京军区普通外科研究所,福州350025 [2]上海交通大学医学院药理教研室,上海200052

出　　处：《国际外科学杂志》2008年第8期510-512,F0003,共4页International Journal of Surgery

基　　金：福建省自然科学基金（No.C0510032）

摘　　要：目的观察山莨菪碱慢性给药对自发性高血压（SHR）大鼠血管功能及血管形态学方面的影响。方法采用SHR大鼠慢性腹腔注射山莨菪碱，10周后急性处死，采用灌注取材法获取腹主动脉，显微镜下观察主动脉的形态学改变。采用离体主动脉环灌流技术，观察山莨菪碱对血管功能的影响。结果生理状态下，长期给予SHR大鼠山莨菪碱，可使高血压大鼠血管内皮及平滑肌舒张功能显著改善；山莨菪碱慢性用药可有效抑制SHR大鼠腹主动脉瘤形成，使血管形态结构发生良性改变。结论慢性山莨菪碱给药，可使SHR大鼠血管内皮及平滑肌功能改善，血管形态结构发生良性改变，提示山莨菪碱具有内皮及平滑肌保护作用。Objective To investigate the influence of Anisodamine chronic administration on the vascular function and morphology of SHR. Methods The SHR were injected by chronic abdominal Anisodamine; Then the SHR were sacrificed after ten weeks. The abdominal aorta were obtained after perfusion and the changes of aorta morphology were observed under a microscope. The influence of Anisodamine on the vasculovr funtion was investigated by the rat＇s aorta tings perfusion. Results In the physiological state, given SHR long-term Anisodamine, the vascular endothelial and smooth muscle relaxation will significantly improve; Anisodamine chronic adminstration can inhibit the formation of aortic aneurysm and change a benign vascular structure. Conclusion Anisodamine chronic adminstration will improve the vascular endothelial and smooth muscle relaxation, and change a benign vascular structure, Anisodamine has a protective effect on endothelial and smooth muscle.

关 键 词：山莨菪碱 主动脉环 血管功能 血管形态 

分 类 号：R544.1[医药卫生—心血管疾病] R322.123[医药卫生—内科学]