支气管哮喘患儿血液脂氧素A_4与白三烯C_4水平的变化  

The changes of blood lipoxin A_4 and leukotriene C_4 in 106 children with asthma

作　　者：殷佩玲[1] 吴升华[2] 

机构地区：[1]南京医科大学附属南京第一医院儿科,210006 [2]南京医科大学第一附属医院儿科

出　　处：《江苏医药》2008年第8期790-791,共2页Jiangsu Medical Journal

摘　　要：目的了解不同严重程度支气管哮喘(哮喘)患儿血液脂氧素A4(LXA4)、白三烯C4(LTC4)水平的变化。方法应用ELISA方法测定106例急性发作期轻、中、重度哮喘患儿血液LXA4、LTC4含量,并与40例正常健康儿童作对照。结果轻、中、重度哮喘患儿血液LXA4水平显著高于对照组(P<0.01),中、重度哮喘患儿血液LXA4水平亦显著高于轻度哮喘患儿(P<0.01),重度哮喘患儿血液LXA4水平显著低于中度哮喘患儿(P<0.01)。轻、中、重度哮喘患儿血液LTC4水平逐渐升高,均显著高于对照组(P<0.01)。结论重度哮喘患儿血液LXA4水平低于中度哮喘患儿,说明体内白三烯的天然生理拮抗物质LXA不足是哮喘加重的原因之一。Objective To investigate the changes of blood lipoxin A4 （LXA4） and leukotriene C4 （LTC4） in children with asthma. Methods The levels of blood LXA4 and LTC4 were determined by ELISA in 106 children with asthma of mild, moderate and severe degree. Normal healthy 40 children were served as the controls. Results The levels of blood LXA4 in children with asthma of mild, moderate and severe degree were higher than those of the controls （P〈0.01）. The levels of blood LXA4 in children with asthma of moderate and severe degree were higher than those in the eases with asthma of mild degree （P〈0. 01）. However, the values of blood LXA4 in children with asthma of severe degree were lower than those in patients with asthma of moderate degree （P〈0.01）. The levels of blood LTC4 were gradually increased in athmatie children illed from mild degree to moderate and severe degree, and all values of blood LTC4 in the patients were higher than those in-the controls （P〈0. 01）. Conclusion The levels of blood LXA4 in children with asthma of severe degree were lower than those in the eases with asthma of moderate degree, suggesting that insufficiency of LXA4, a physiological antagonist on leukotriene in human body, is one of the reasons for asthma deterioration,

关 键 词：脂氧素 白三烯 哮喘 儿童 

分 类 号：R725[医药卫生—儿科]