可多华、戴芬联合治疗慢性前列腺炎/慢性盆底疼痛综合征  

Combined therapy for chronic prostatitis /chronic pelvic pain syndrome with doxazosin and diclofenac

作　　者：吴宗林[1] 夏术阶[2] 耿和[1] 朱洪炜[1] 唐炯[1] 张涛[1] 冯矗[1] 

机构地区：[1]上海市普陀区人民医院泌尿外科,上海200060 [2]上海交通大学附属第一人民医院泌尿外科

出　　处：《中国男科学杂志》2008年第7期20-22,25,共4页Chinese Journal of Andrology

摘　　要：目的探讨可多华和戴芬联合治疗慢性前列腺炎/慢性盆底疼痛综合征的疗效。方法将123例慢性前列腺炎/慢性盆底疼痛综合征的患者,随机分成3组,即可多华组、戴芬组和可多华+戴芬联合治疗组,每组均治疗12周。治疗前以及在治疗12周后分别检测慢性前列腺炎症状积分指数(NIH-CPSI)。结果有115名患者完成了12周的治疗并最终接受评估,可多华组39例,NIH-CPSI总分由治疗前的24.1±2.2下降到治疗后的18.51±1.67,平均下降5.59分(23%)(P<0.001);戴芬组37例,NIH-CPSI总分由治疗前的23.95±2.17下降到治疗后的18.14±1.69,平均下降5.81(24%)(P<0.001);可多华+戴芬组39例,NIH-CPSI总分由治疗前的23.82±1.72下降到治疗后的16.77±1.37,平均下降7.05分(30%)(P<0.001)。结论可多华、戴芬均能有效缓解慢性前列腺炎/慢性盆底疼痛综合征患者的症状,改善患者的生活质量,但可多华+戴芬联合治疗组疗效优于单一治疗组。Objective To evaluate the clinical effect of combined therapy for chronic prostatitis/chronic pelvic pain syndrome with doxazosin and diclofenac. Methods The total of i23 patients,who were 20-50 years old, with ehfonic prostatitis/chronic pelvic pain syndrome were randomly divided into three groups including doxazosin group, diclofenac group, and combined therapy group. All patients who were assessed by the National Institutes of Health- Chronic Prostatitis Symptom Index （NIH-CPSI） before and after treatment received treatment for 12 weeks. Results 115 patients were valid cases for assessment analysis. The score of NIH-CPSI decreased from 24.1±2.2 to 18.51±1.67 pre- and post-treatment in doxazosin group（39 cases）; 23.95±2.17 to 18.14±1.69 in diclofenac group; and 23.82±1.72 to 16.77±1.37 in combined therapy group. Conclusion The chronic prostatitis/chronic pelvic pain syndrome treated With doxazosin, diclofenac or combined therapy were all effective in alleviating the symptoms and improving the quality of life, and meanwhile combined therapy was found to be superior to single therapy in symptomatic relief.

关 键 词：盆腔疼痛 前列腺炎 药物治疗 

分 类 号：R697.33[医药卫生—泌尿科学]