糖尿病肢体动脉闭塞症与闭塞性动脉硬化症血管张力因素改变的对比  

Constrasting Study of Vascular Tension Factors between Diabetic Arterial Occlusion and Arteriosclerosis Obliterans

作　　者：陈柏楠[1] 秦红松[1] 刘政[1] 任晋蒙[2] 许永楷[2] 

机构地区：[1]山东中医药大学附属医院周围血管病科,济南2500114 [2]山东中医药大学

出　　处：《中国中西医结合外科杂志》2008年第4期337-339,共3页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：山东省中医管理局中医药科技计划项目(2005-176)

摘　　要：目的：研究糖尿病肢体动脉闭塞症与闭塞性动脉硬化症，血管收缩因素内皮素-1（ET-1）、血栓素A2（TXA2）和血管舒张因素一氧化氮（N0）、前列环素（PGl2）的各自变化特点。方法：将40例糖尿病肢体动脉闭塞症设为I组，50例闭塞性动脉硬化症设为Ⅱ组，30例正常对照设为Ⅲ组。应用放射免疫方法测定血浆ET-1、NO、血栓素B2（TXB2）和6-酮-前列腺素F1a（6-keto-PGFla）浓度。结果：（1）病变各组的ET-1水平均高于对照组（P〈0．01．0．05）；I组高于Ⅱ组，并差异有显著性（P〈0．01）。（2）病变各组NO水平均低于对照组（P〈0．01～0．05），病变组之间差异无显著性（P〉0．05）。（3）病变各组TXB2水平均高于对照组（P〈0．01）；I组高于Ⅱ组，并差异有显著性（P〈0．05）。（4）病变各组6-keto-PGFla水平均低于对照组（P〈0．05），病变组之间差异无显著性（P〉0．05）。结论：糖尿病肢体动脉闭塞症与闭塞性动脉硬化症均存在血管张力因素的变化，血管收缩因素明显增强，血管舒张因素明显降低。糖尿病肢体动脉闭塞症患者血管收缩因素和血栓形成因素明显高于闭塞性动脉硬化症患者，而血管舒张因素的受损程度二者无明显差异。Abstract：Objective To study thc characteristic changes and differences of endothelin-l（ET-1）,throroboxane A2 （TXA2）, nitric oxidc（NO）, and prostacyclin（PGE1 ）between diabetic arterial occlusion and arteriosclerosis obliterans. Methods Ninety cases（including 40 patients with diabetic arterial occlusion, 50 with arteriosclerosis obliterans and 30 healthy people as control） were observeda by measuring the levels of ET-1, NO, TXB2 and 6-keto-PGFla in plasma with radioimmunoassay. Results 1. The levels of ET- 1 in all patients were higher than those in control group （ P 〈 0.01 -0.05）; the levels in oatients with diabetic arterial occlusion were higher than those in patients with arteriosclerosis obliterans with significant difference （ P 〈 0.01 ） ; 2. Thc levels of NO in all patients were lower than those in control group （ P 〈 0.01 - 0.05）, and there was no significant difference between the diabetic arterial occlusion and thc arteriosclerosis obliterans（ P 〉 0.05 ） ; 3. The levels of TXB2 in all patients were higher than those in control group （P 〈 0.01 -0.05）;the levels in diabetic arterial occlusion were higher than those in arteriosclerosis oblitersns with significant differences （ P 〈 0.05） ; 4. The levels of 6 - kcto - PGFla. in all pa- tients were lower than thosc in control group（ P 〈 0.01 -0.05）, and there was no significant differencc between those in diabetic arterial occlusion and those in arteriosclerosis obliterans（ P 〉 0.05）. Conclusion There are vascular tension factor changes both in diabetic arterial occlusion and arteriosclerosis obliterans, manifesting as increase of vascular contractive factor and a decrease of vascular dilative factor. The vascular contractive factors and thrombotic factors of diabetic arterial occlusion are obviously higher than those of arteriosclerosis oblitersns, the changcs of vascular dilative factors in the two diseases show insignificant differences.

关 键 词：糖尿病 肢体动脉闭塞 血管张力 

分 类 号：R587.1[医药卫生—内分泌] R543.5[医药卫生—内科学]