276例6月龄以下婴儿ABO血型IgM抗体分析  

Frequency of ABO Type IgM Antibody in 276 Infants Younger than Six Months

作　　者：马曙轩[1] 徐樨巍[1] 宋文琪[1] 邵华[1] 薛晖[1] 张清秀[1] 

机构地区：[1]首都医科大学北京儿童医院检验中心,北京100045

出　　处：《中国实验血液学杂志》2008年第4期919-921,共3页Journal of Experimental Hematology

摘　　要：本研究探讨6个月以下婴儿ABO血型IgM抗体产生频率。选取我院6个月龄以下住院患儿309例,采集EDTA K3抗凝静脉血标本,依据患儿年龄不同分为5组:出生1周以内的早期新生儿为Ⅰ组;出生8天至2周的新生儿为Ⅱ组;出生15天至1个月新生儿为Ⅲ组;2个月至3个月龄的婴儿为Ⅳ组;4个月至6个月龄的婴儿为Ⅴ组。应用单克隆抗A、抗B血清、A细胞、B细胞及O细胞进行试管法血型检定。结果表明:在检测新生儿及婴儿标本309例中舍去AB型标本33例,其余276例标本中Ⅰ组患儿46例,其中29例检出抗体,正反定型符合率63%(29/46);Ⅱ组患儿64例,其中41例检出抗体,正反定型符合率64%(41/64);Ⅲ组患儿74例,其中47例检出抗体,正反定型符合率63%(47/74);Ⅳ组患儿45例,其中28例检出抗体,正反定型符合率62%(28/45)。Ⅴ组患儿47例,其中40例检出抗体,正反定型符合率85%。结论:有相当一部分新生儿和6月龄以下婴儿体内已产生ABO血型IgM抗体,这可作为婴儿ABO血型检定的重要佐证。The aim of study was to explore the frequency of ABO type IgM antibody in infants younger than six months. 309 hospitalized infants younger than six months were selected at first and their EDTA K3 anticoagulant blood samples were taken. All the infants were devided into five groups： neonates within 1 week as group Ⅰ ; neonates aged 8 to 14 days as group Ⅱ ; neonates aged 15 days to 1 month as group Ⅲ; infants aged two to 3 months as group Ⅳ and infants aged 4 to 6 months as group Ⅴ. The monocolonal anti-A, anti - B serums, A cells, B cells and O cells were utilized to carried out the blood typing with tube test. The results indicated that from 309 samples tested 33 AB type sample were excluded. Out of the remains of 276 samples, 29 of 46 samples in group Ⅰ were positive and with the ABO type consistent rate 63 % （29/46） ; 41 of 64 samples in group Ⅱ were positive and with the ABO type consistent rate 64% （41/64） ; 47 of 74 samples in group Ⅲ were postive and with the ABO type consistent rate 63% （47/74） ; 28 of 45 samples in group Ⅳ were positive and with the ABO type consistent rate 62% （ 28/45 ） ; 40 of 47 samples in group Ⅴ were positive and with the ABO type consistent rate 85%. It is concluded that the ABO type IgM antibody appear in mostinfants younger than six months and these IgM antibodies may be regarded as the important evidence for ABO typing in infants.

关 键 词：新生儿 婴儿 ABO血型 IGM抗体 

分 类 号：R457.11[医药卫生—治疗学]